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A Study of Orforglipron (LY3502970) Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin

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研究单位: [1]Eli Lilly and Company [2]Alliance Research Institute - Canoga Park,Canoga Park,California,United States,91304 [3]Ark Clinical Research,Long Beach,California,United States,90815 [4]Collaborative Neuroscience Research, LLC,Los Alamitos,California,United States,90720 [5]Wolverine Clinical Trials,Santa Ana,California,United States,92705 [6]CMR of Greater New Haven,Hamden,Connecticut,United States,06517 [7]Institute of Endocrinology Diabetes, Health & Hormone,Stockbridge,Georgia,United States,30281 [8]Elite Clinical Trials,Rexburg,Idaho,United States,83440 [9]Accellacare - DuPage,Lombard,Illinois,United States,60148 [10]Tandem Clinical Research,Marrero,Louisiana,United States,70072 [11]St. Vincent Healthcare,Billings,Montana,United States,59101 [12]Albuquerque Clinical Trials, Inc.,Albuquerque,New Mexico,United States,87102 [13]Accellacare - Winston-Salem,Winston-Salem,North Carolina,United States,27103 [14]Alliance for Multispecialty Research, LLC,Norman,Oklahoma,United States,73069 [15]Essential Medical Research,Tulsa,Oklahoma,United States,74137 [16]Accellacare - Mt Pleasant,Mount Pleasant,South Carolina,United States,29464 [17]Accellacare, US Inc., d/b/a Accellacare of Knoxville,Jefferson City,Tennessee,United States,37760 [18]Dallas Diabetes Research Center,Dallas,Texas,United States,75230 [19]Juno Research,Houston,Texas,United States,77040 [20]Consano Clinical Research, LLC,Shavano Park,Texas,United States,78231 [21]The Second People''s Hospital of Hefei,Hefei,Anhui,China,230011 [22]The Fourth Hospital of Harbin Medical University,Harbin,Heilongjiang,China,150001 [23]The First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan,China,473007 [24]The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450014 [25]Nanjing First Hospital,Nanjing,Jiangsu,China,210006 [26]The Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu,China,210011 [27]The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu,China,215006 [28]Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu,China,212000 [29]Jinan Central Hospital,Jinan,Shandong,China,250013 [30]Shanghai Sixth People''s Hospital,Shanghai,Shanghai,China [31]First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China,650032 [32]The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China,325000 [33]CRS Clinical Research Services Mannheim,Mannheim,Baden-Württemberg,Germany,68167 [34]Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz,Lingen,Niedersachsen,Germany,49808 [35]Diabetes- und Stoffwechselpraxis Bochum,Bochum,Nordrhein-Westfalen,Germany,44869 [36]InnoDiab Forschung Gmbh,Essen,Nordrhein-Westfalen,Germany,45136 [37]Medizentrum Essen Borbeck,Essen,Nordrhein-Westfalen,Germany,45355 [38]Zentrum fur klinische Forschung - Köln,Köln,Nordrhein-Westfalen,Germany,51069 [39]Institut für Diabetesforschung GmbH Münster,Münster,Nordrhein-Westfalen,Germany,48145 [40]Diabetologikum Ludwigshafen/Die Praxis am Ludwigsplatz,Ludwigshafen am Rhein,Rheinland-Pfalz,Germany,67059 [41]Diabetologische Schwerpunktpraxis und Praxis für Allgemeinmedizin Dr. Veronika Wenzl-Bauer null Josef Wenzl,Rehlingen,Saarland,Germany,66780 [42]Zentrum für klinische Studien,St.Ingbert,Saarland,Germany,66386 [43]RED-Institut GmbH,Oldenburg,Schleswig-Holstein,Germany,23758 [44]Diabetes Zentrum Wilhelmsburg,Hamburg,Germany,21109 [45]Cryptex Investigación Clínica S.A. de C.V.,Cuauhtémoc,Distrito Federal,Mexico,06100 [46]ProcliniQ Investigación Clínica SA de CV,Mexico City,Distrito Federal,Mexico,14050 [47]Grupo Ollin Care,Pachuca,Hidalgo,Mexico,42000 [48]Instituto Jalisciense de Investigacion en Diabetes y Obesidad,Guadalajara,Jalisco,Mexico,44600 [49]Instituto de Diabetes, Obesidad y Nutricion,Cuernavaca,Morelos,Mexico,62250 [50]Cardiolink Clin Trials,Monterrey,Nuevo León,Mexico,64060 [51]Clínica García Flores SC,Monterrey,Nuevo León,M

研究目的:
The main purpose of this study is to assess the safety and efficacy of orforglipron compared with dapagliflozin in improving blood sugar control in participants with type 2 diabetes (T2D) with inadequate glycemic control using metformin. The study will last approximately 46 weeks.

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