研究单位：[1]Zhongda Hospital[2]Zhongda Hospital[3]Xijing Hospital, Air Force Medical University[4]First Affiliated Hospital, Sun Yat-Sen University[5]Zhongnan University Xiangya Second Hospital[6]Renmin Hospital of Wuhan University[7]First Affiliated Hospital of Suzhou Medical College[8]The First Affiliated Hospital of Nanchang University[9]The Third Bethune Hospital of Jilin University[10]Zhongnan Hospital[11]First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital)[12]First Affiliated Hospital of the Xi'an Jiaotong University[13]First Affiliated Hospital of Kunming Medical University[14]Sichuan Academy of Medical Sciences[15]Anhui provincial chest hospital[16]The Guangxi Zhuang Autonomous Region People's Hospital[17]Second Affiliated Hospital of Suzhou University[18]The Ninth People's Hospital of Suzhou[19]Fifth Affiliated Hospital of Xinjiang Medical University[20]Xuzhou Medical University Hospital[21]First People's Hospital of Hangzhou[22]Hebei Medical University Fourth Hospital[23]Huai'an First People's Hospital[24]Jinan City People's Hospital[25]The First People's Hospital of Lianyungang[26]Jiangsu Subei People's Hospital[27]Suqian First People's Hospital[28]Tai'an City Central Hospital[29]Xuzhou Central Hospital[30]The first People's Hospital of Yancheng City[31]The First People's Hospital of Zunyi[32]Jiangxi Provincial People's Hopital[33]Henan Provincial People's Hospital
Sedatives are the mostly common prescription for patients with mechanical ventilation due to the disease or therapies. Ciprofol is a new intravenous anesthetic agent transformed from propofol, and has a similar sedative effect of propofol in previous study. Whether ciprofol is safe and effective similar with propofol for sedation in ICU patients with mechanical ventilation? Therefor, a multi-center, double-blind, randomized control trial was conducted with a noninferiority design, to compared the rate of successful sedation without hypotension of sedation by ciprofol or propofol in ICU patients with mechanical ventilation. A Multi-Center, Double-Blind, Randomized Controlled Trial will be launched to evaluate the efficacy and safety of ciprofol versus propofol for sedation in ICU patients with mechanical ventilation.
