Drug-induced liver injury (DILI) arising from chemicals or therapeutic drugs is mainly responsible for liver diseases, which makes the early diagnosis of DILI particularly important. Herein, we developed a targeted probe of zinc-bis(dipicolylamine) conjugated cyanine dye (Cy7-ZnDPA), in which ZnDPA would target phosphatidylserine (PS) on the surface of apoptotic cells of DILI. Moreover, Cy-ZnDPA could overcome the tissue penetration depth and precisely locate the lesion area by means of high-resolution fluorescence and photoacoustic imaging in the DILI mice model. Cy-ZnDPA is expected to be a powerful probe for the diagnosis of other apoptotic related physiological and pathological processes.
语种：
外文
WOS：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区材料科学
小类|1 区材料科学：纺织2 区应用化学2 区工程：化工
最新[2023]版：
大类|3 区工程技术
小类|1 区材料科学：纺织2 区应用化学3 区工程：化工
JCR分区：
出版当年[2021]版：
Q1CHEMISTRY, APPLIEDQ1MATERIALS SCIENCE, TEXTILESQ2ENGINEERING, CHEMICAL
第一作者机构：[1]Coll Chem & Mat Sci, Minist Educ, Shanghai Key Lab Rare Earth Funct Mat, Key Lab Resource Chem, Shanghai 200234, Peoples R China[2]Shanghai Normal Univ, Shanghai 200234, Peoples R China[*1]Coll Chem & Mat Sci, Minist Educ, Shanghai Key Lab Rare Earth Funct Mat, Key Lab Resource Chem, Shanghai 200234, Peoples R China[*2]Shanghai Normal Univ, Shanghai 200234, Peoples R China
通讯作者：
通讯机构：[1]Coll Chem & Mat Sci, Minist Educ, Shanghai Key Lab Rare Earth Funct Mat, Key Lab Resource Chem, Shanghai 200234, Peoples R China[*1]Coll Chem & Mat Sci, Minist Educ, Shanghai Key Lab Rare Earth Funct Mat, Key Lab Resource Chem, Shanghai 200234, Peoples R China[2]Shanghai Normal Univ, Shanghai 200234, Peoples R China[*2]Shanghai Normal Univ, Shanghai 200234, Peoples R China[3]Kunming Med Univ, Hosp Affiliated 1, Kunming 650031, Yunnan, Peoples R China[*3]Kunming Med Univ, Hosp Affiliated 1, Kunming 650031, Yunnan, Peoples R China
推荐引用方式(GB/T 7714)：
Zhou Zhiguo,Zhou Han,Zhang Kang,et al.ZnDPA-conjugated cyanine probes for targeted near-infrared fluorescence and photoacoustic imaging of drug-induced liver injury in vivo[J].DYES AND PIGMENTS.2021,194:doi:10.1016/j.dyepig.2021.109586.
APA：
Zhou, Zhiguo,Zhou, Han,Zhang, Kang,Wang, Yaning,Gao, Yucong...&Yang, Shiping.(2021).ZnDPA-conjugated cyanine probes for targeted near-infrared fluorescence and photoacoustic imaging of drug-induced liver injury in vivo.DYES AND PIGMENTS,194,
MLA：
Zhou, Zhiguo,et al."ZnDPA-conjugated cyanine probes for targeted near-infrared fluorescence and photoacoustic imaging of drug-induced liver injury in vivo".DYES AND PIGMENTS 194.(2021)
材料科学