Objective FOXP3 single nucleotide polymorphisms (SNPs) were recently elucidated to influence the development of preeclampsia (PE), but the results on this issue still remained controversial. Thus, a meta-analysis was implemented to systematically investigate the roles of FOXP3 SNPs in PE. Methods Eligible publications were identified by retrieving relevant electronic databases. Meanwhile, the association intensity was estimated by calculating odds ratios (ORs) and 95% confidence intervals (CIs) in various genetic models. Results Totally eight investigations involving 3446 subjects were enrolled in the final meta-analysis. The AC and AC + CC genotypes of FOXP3 rs3761548 were related to the susceptibility of PE in over-dominant (OR = 1.19, 95%CI = 1.02-1.38, P = 0.03) and recessive (OR = 0.59, 95% CI: 0.36-0.97, P = 0.04) models. Furthermore, correlation between rs2232365 and PE was observed in recessive model (GG vs. GA + AA) (OR = 0.79, 95%CI: 0.65-0.97, P = 0.03). Moreover, rs2232365 GA and GG + GA genotypes were associated with the severity of PE. However, rs4824747, rs3761547 and rs2280883 polymorphisms had no significant impact on PE susceptibility. Conclusions FOXP3 rs3761548 and rs2232365 SNPs influenced the PE susceptibility and therefore may be potential biomarkers for prediction of PE risk.
基金:
National Nature Science Foundation of China [81960664]; Science and Technology Planning Project of 920th Hospital of Joint Logistics Support Force [2020YGB11]
第一作者机构:[1]920th Hosp Joint Logist Support Force, Dept Clin Pharm, 212 Daguan Rd, Kunming 650032, Yunnan, Peoples R China[2]Dali Univ, Coll Pharm, Dali, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]920th Hosp Joint Logist Support Force, Dept Clin Pharm, 212 Daguan Rd, Kunming 650032, Yunnan, Peoples R China[*1]920th Hosp Joint Logist Support Force, Dept Clin Pharm, 212 Daguan Rd, Kunming 650032, Yunnan, Peoples R China
推荐引用方式(GB/T 7714):
Fan Yu-Xin,Wu Jiang-Hai,Yin Sun-Jun,et al.Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta-analysis[J].AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY.2022,88(1):e13554.doi:10.1111/aji.13554.
APA:
Fan, Yu-Xin,Wu, Jiang-Hai,Yin, Sun-Jun,Zhou, Tao,Huang, Yan-Hua...&He, Gong-Hao.(2022).Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta-analysis.AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY,88,(1)
MLA:
Fan, Yu-Xin,et al."Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta-analysis".AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 88..1(2022)