Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and "pre-necrotic" biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.
基金：
National Natural Science Foundation of China [81860073, 81760074, 82160439]; Yunnan Provincial Department of Science and Technology [202001AT070039]; Yunnan Health Training Project of High-Level Talents [H-2018032]; 100 Young and Middle-aged Academic and Technical Backbones of Kunming Medical University [60118260106]; Young Talents of Yunnan Thousand Talents Plan [YNQR-QNRC-2019-006, RLQN20200002]; Graduate Student Innovation Fund of Kunming Medical University [2022S035]; Clinical Medical Center for Cardiovascular and Cerebrovascular Disease of Yunnan Province, China [ZX2019-03-01]
第一作者机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Cardiol, Kunming 650032, Peoples R China
通讯作者：
通讯机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Cardiol, Kunming 650032, Peoples R China[*1]Kunming Med Univ, Affiliated Hosp 1, Dept Cardiol, Kunming 650032, Peoples R China
推荐引用方式(GB/T 7714)：
Li Jingru,Ma Haocheng,Wu Xinyu,et al.Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction[J].JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B.2023,24(4):281-300.doi:10.1631/jzus.B2200459.
APA：
Li, Jingru,Ma, Haocheng,Wu, Xinyu,Sun, Guihu,Yang, Ping...&Wang, Luqiao.(2023).Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,24,(4)
MLA：
Li, Jingru,et al."Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 24..4(2023):281-300
