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The prognostic and clinicopathological roles of microsatellite instability, PD-L1 expression and tumor-infiltrating leukocytes in familial adenomatous polyposis.

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机构： [1]Department of Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. [2]Department of Internal Medicine-Oncology, Yunnan Cancer Hospital, Kunming, 650106, China. [3]Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China

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Microsatellite instability, programmed death-ligand 1 and tumor-infiltrating leukocytes are prognostic biomarkers in colorectal cancer but unknown toward familial adenomatous polyposis.To investigate the prognostic and clinicopathological roles of microsatellite instability, programmed death-ligand 1 and tumor-infiltrating leukocytes in familial adenomatous polyposis.Clinical data and paraffin embedded tissues from 45 familial adenomatous polyposis patients were collected. Microsatellite instability was detected by immunohistochemistry and polymerase chain reaction. Programmed death-ligand 1 was detected by immunohistochemistry. Tumor-infiltrating leukocytes comprising CD8+ T cells, M1 and M2 tumor associated macrophages, CD56bright and CD56dim natural killer cells were analyzed using multiple fluorescence immunohistochemistry.Microsatellite instability high was noted in 6 samples but not associated with overall survival or progression-free survival. Programmed death-ligand 1 is negative on tumor cells but positive on tumor-infiltrating leukocytes, and positive programmed death-ligand 1 expression on tumor-infiltrating leucocytes is associated with overall survival. Low CD56bright natural killer cell infiltration was associated with longer progression-free survival and was an independent prognostic factor in FAP.For familial adenomatous polyposis, microsatellite instability high can be found but has no correlation with prognosis; programmed death-ligand 1 on tumor-infiltrating leukocytes is related with overall survival; CD56bright natural killer cell is an independent prognostic factor associating with longer progression-free survival.Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区肿瘤学 2 区外科

最新[2023]版：

大类 | 2 区医学

小类 | 2 区肿瘤学 2 区外科

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出版当年[2022]版：

Q1 SURGERY Q2 ONCOLOGY

最新[2023]版：

Q1 SURGERY Q2 ONCOLOGY

影响因子： 3.5 最新[2023版] 3.6 最新五年平均 3.8 出版当年[2022版] 4 出版当年五年平均 4.037 出版前一年[2021版] 3.5 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

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通讯机构： [1]Department of Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. [*1]Department of Oncology, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Rd, Kunming, 650032, China.

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