个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Diagnostic value of abnormal chromosome 3p genes in small-cell lung cancer.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Ma Chunxu[1] ; Zhao Jihua[1] ; Wu Ying[1] ; Wang Jun[2,*2] ; Wang Hao[1,3,*1] ;
机构： [1]Department of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000 [2]College of Physical Education, Yunnan Agricultural University, Kunming, Yunnan 650201 [3]Department of Nuclear Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, UESTC, Chengdu, Sichuan 610072, P.R. China
出处：
DOI： 10.3892/ol.2022.13330
ISSN：

关键词： diagnosis small‑cell lung cancer chromosome 3p gene reverse transcription‑quantitative PCR drug prediction

摘要：
The diagnosis of small cell lung carcinoma (SCLC) remains a great challenge. Changes in chromosome 3p (chr3) genes are usually observed in the pathogenesis of lung cancer, which suggests that these chr3 genes may be a diagnostic marker in the early stage of SCLC. The present study explored the diagnostic value of the chr3 gene in SCLC using Bioinformatics. Furthermore, reverse transcription-quantitative PCR (RT-qPCR) was used to reveal the expression patterns of diagnostic biomarkers in human pulmonary alveolar epithelial cells and in the SCLC cell line NCI-H146. A total of 33 differentially expressed (DE) chr3 genes and 1,156 module genes associated with clinical features of patients with SCLC were identified and functional enrichment analysis indicated that all these genes were significantly enriched in cell cycle terms. The area under the receiver operating characteristic curve demonstrated that the overlapping genes of the DE-chr3 and module genes, namely cell division cycle 25 A (CDC25A), FYVE and coiled-coil domain autophagy adaptor 1 (FYCO1) and lipid raft linker 1 (RFTN1), were relatively accurate in distinguishing normal from SCLC samples, and may thus be considered diagnostic biomarkers. CDC25A was overexpressed in SCLC samples, while FYCO1 and RFTN1 were highly expressed in normal samples, as evidenced by the RT-qPCR results. Single-gene gene set enrichment analysis suggested that the diagnostic biomarkers were significantly associated with cell cycle, ATP-binding cassette transporter, immune cell differentiation, immune response and multiple respiratory disease pathways. Furthermore, a total of 141 drugs were predicted by The Comparative Toxicogenomics Database to be able to modulate the expression of the diagnostic biomarkers, of which 8 drugs were shared among the three aforementioned diagnostic biomarkers. The present study identified three novel and powerful diagnostic biomarkers for SCLC based on chr3 genes. Suggestions for the development and selection of drugs for clinical treatment based on diagnostic biomarkers were also provided.Copyright: © Ma et al.

基金：
This research was funded by the Natural Science Foundation of China (grant no. 81960320), the Priority Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University (grant no. 202001AY070001‑199) and the Yunnan Health Training Project of High Level Talents (grant no. D‑2019025).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2022]版：
Q3 ONCOLOGY
最新[2023]版：
Q3 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000
共同第一作者：
通讯作者：
通讯机构： [1]Department of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000 [2]College of Physical Education, Yunnan Agricultural University, Kunming, Yunnan 650201 [3]Department of Nuclear Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, UESTC, Chengdu, Sichuan 610072, P.R. China [*1]Department of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan 650000, P.R. China [*2]College of Physical Education, Yunnan Agricultural University, 452 Fengyuan Road, Kunming, Yunnan 650201, P.R. China
推荐引用方式(GB/T 7714)：
Ma Chunxu,Zhao Jihua,Wu Ying,et al.Diagnostic value of abnormal chromosome 3p genes in small-cell lung cancer.[J].ONCOLOGY LETTERS.2022,24(1):doi:10.3892/ol.2022.13330.
APA：
Ma Chunxu,Zhao Jihua,Wu Ying,Wang Jun&Wang Hao.(2022).Diagnostic value of abnormal chromosome 3p genes in small-cell lung cancer..ONCOLOGY LETTERS,24,(1)
MLA：
Ma Chunxu,et al."Diagnostic value of abnormal chromosome 3p genes in small-cell lung cancer.".ONCOLOGY LETTERS 24..1(2022)

相关文献

[1]非小细胞肺癌A549和H520细胞PDCD4和AP-1表达与细胞迁移的相关性研究 [2]Metformin promotes survivin degradation through AMPK/PKA/GSK-3-axis in non-small cell lung cancer [3]Prognostic value of CD44 expression in non-small cell lung cancer: a systematic review [4]Causal role of metabolites in non-small cell lung cancer: Mendelian randomization (MR) study [5]High levels of MESP1 expression in non-small cell lung cancer can facilitate cell proliferation, metastasis and suppresses cell apoptosis [6]NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer [7]GRK5 functions as an oncogenic factor in non-small-cell lung cancer [8]Genomic profiling of non-small cell lung cancer in Xuanwei, Yunnan Province [9]Downregulation of MMP-9 by epicatechin can improve the radiosensitivity of non-small cell lung cancer [10]Clinical significance of CD151 expression in non-small cell lung cancer

资源点击量：53661 今日访问量：0 总访问量：1665 更新日期：2024-11-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 昆明医科大学第一附属医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西昌路295号(650032)