机构：[1]Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha 410008, Hunan, Peoples R China[2]Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China[3]Kunming Med Univ,Affiliated Hosp 1,Dept Reprod & Genet,Kunming,Peoples R China昆明医科大学附属第一医院外科科室生殖遗传科[4]Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosis could lead to inflammation and a variety of diseases. In this study, we reviewed the molecular mechanism underlying necroptosis, and discuss its role in the pathogenesis of various diseases. Finally, we summarize several current inhibitors of necroptosis and discuss the potential of targeting necroptosis as a therapeutic strategy for various diseases.
基金：
National Natural Science Foundation of China; [81900069]; [82000697]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区医学
小类|1 区药学2 区医学：研究与实验
最新[2023]版：
大类|2 区医学
小类|1 区药学2 区医学：研究与实验
JCR分区：
出版当年[2022]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha 410008, Hunan, Peoples R China[2]Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China
通讯作者：
通讯机构：[1]Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha 410008, Hunan, Peoples R China[4]Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China[*1]Department of Nutrition, Xiangya Hospital, Central South University,Changsha 410008, Hunan, China
推荐引用方式(GB/T 7714)：
Yang Ming,Chen Wei,He Liyu,et al.A Glimpse of necroptosis and diseases[J].BIOMEDICINE & PHARMACOTHERAPY.2022,156:doi:10.1016/j.biopha.2022.113925.
APA：
Yang, Ming,Chen, Wei,He, Liyu,Liu, Di,Zhao, Li&Wang, Xi.(2022).A Glimpse of necroptosis and diseases.BIOMEDICINE & PHARMACOTHERAPY,156,
MLA：
Yang, Ming,et al."A Glimpse of necroptosis and diseases".BIOMEDICINE & PHARMACOTHERAPY 156.(2022)
医学