Objective: Our objective was to conduct a meta-analysis to investigate the clinicopathological features and prognostic value of programmed cell death ligand 1 (PD-L1) expression in patients with urothelial carcinoma (UC). Materials and methods: Twenty-seven studies with 4,032 patients were included in the meta-analysis. Pooled ORs and 95% CIs were used to examine the associations between clinical factors and PD-L1 expression. HRs and 95% CIs were extracted from eligible studies. Heterogeneity was evaluated using the chi-squared-based Q test and I-2 statistic. Results: Expression of PD-L1 on tumor cells (TCs) was associated with muscle-invasive disease (OR=3.67, 95% CI: 2.53-5.33), and inversely associated with the history of intravesical bacilli Calmette-Guerin therapy (OR=0.39, 95% CI: 0.18-0.82) in bladder cancer patients. PD-L1 expression on TCs was associated with worse overall survival (HR=2.06, 95% CI: 1.38-3.06) in patients with organ-confined bladder cancer. PD-L1 expression in patients with UC was significantly related to better objective response rate after PD-1/PD-L1 antibody treatment. Conclusions: Expression of PD-L1 on TCs was associated with muscle-invasive disease in patients with bladder cancer. Patients with PD-L1-positive UC had a significantly better response to PD-1/PD-L1 targeted treatment.
基金:
Project of National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81860453, 81602644]; Basic Scientific Research Operating Expenses for Central Universities [buctrc201910]; Major Project of Yunnan Provincial Department of Science and Technology Item [2018ZF009]; National Key Research and Development Program [2017YFA0105900]
第一作者机构:[1]Kunming Med Univ, Affiliated Hosp 2, Dept Urol, Kunming, Yunnan, Peoples R China
通讯作者:
通讯机构:[1]Kunming Med Univ, Affiliated Hosp 2, Dept Urol, Kunming, Yunnan, Peoples R China
推荐引用方式(GB/T 7714):
Ding Xiangli,Chen Qiaochao,Yang Zhao,et al.Clinicopathological and prognostic value of PD-L1 in urothelial carcinoma: a meta-analysis[J].CANCER MANAGEMENT AND RESEARCH.2019,11:4171-4184.doi:10.2147/CMAR.S176937.
APA:
Ding, Xiangli,Chen, Qiaochao,Yang, Zhao,Li, Jun,Zhan, Hui...&Yang, Delin.(2019).Clinicopathological and prognostic value of PD-L1 in urothelial carcinoma: a meta-analysis.CANCER MANAGEMENT AND RESEARCH,11,
MLA:
Ding, Xiangli,et al."Clinicopathological and prognostic value of PD-L1 in urothelial carcinoma: a meta-analysis".CANCER MANAGEMENT AND RESEARCH 11.(2019):4171-4184