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Integrative stemness characteristics associated with prognosis and the immune microenvironment in lung adenocarcinoma

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机构： [1]Department of Thoracic Surgery, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, 650031 Kunming, Yunnan, China [2]Department of Thoracic Surgery, Yan’an Hospital of Kunming, 650000 Kunming, Yunnan, China [3]Department of Thoracic Surgery, The Affiliated Anning First People’s Hospital, Kunming University of Science and Technology, Kunming Fourth People’s Hospital, No. 2 Ganghe Road, Wanghu Neighborhood Committee, Jinfang Street, 650302 Anning, Yunnan, China [4]The IVD Medical Marketing Department, 3D Medicines Inc, 201114 Shanghai, China [5]Department of Thoracic Surgery, the First Affiliated Hospital of Kunming Medical University, 650031 Kunming, Yunman, China

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关键词： Lung adenocarcinoma Tumor microenvironent Prognosis Stemness mRNAsi

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To comprehensively analyze the stemness characteristics related to prognosis and the immune microenvironment in lung adenocarcinoma (LUAD).The OCLR machine learning method was used to calculate the stemness index (mRNAsi) of the LUAD samples. DEGs common between the low mRNAsi, normal, and high mRNAsi groups were screened and the immune-stemness genes were obtained. Then the PPI network was created and enrichment analyses were performed. Moreover, different subtypes based on immune-stemness genes associated with prognosis were identified, and the relationships between LUAD stemness and TIME variables were systematically analyzed, followed by TMB analysis.Patients in the high mRNAsi groups with poor prognosis were screened along with 144 immune-stemness genes. IL-6, FPR2, and RLN3 showed a higher degree in the PPI network. A total of 26 immune-stemness genes associated with prognosis were screened. Two clusters were obtained (cluster 1 and cluster 2). Survival analysis revealed that patients in cluster 2 had a poor prognosis. A total of 12 immune cell subpopulations exhibited significant differences between cluster 1 and cluster 2 (P < 0.05). A total of 10 immune checkpoint genes exhibited significantly higher expression in cluster 1 (P < 0.05) than in cluster 2. Further, the TMB value in cluster 2 was higher than that in cluster 1 (P < 0.05).Immune-stemness genes, including L-6, FPR2, and RLN3, might play significant roles in LUAD development via cytokine-cytokine receptor interaction, neuroactive ligand‒receptor interaction, and the JAK‒STAT pathway. Immune-stemness genes were related to tumor-infiltrating immune cells, TMB, and expression of immune checkpoint gene.© 2022. The Author(s).

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区呼吸系统

最新[2023]版：

大类 | 3 区医学

小类 | 3 区呼吸系统

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出版当年[2022]版：

Q3 RESPIRATORY SYSTEM

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Q2 RESPIRATORY SYSTEM

影响因子： 2.6 最新[2023版] 3 最新五年平均 3.1 出版当年[2022版] 3.5 出版当年五年平均 3.32 出版前一年[2021版] 2.6 出版后一年[2023版]

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第一作者机构： [1]Department of Thoracic Surgery, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, 650031 Kunming, Yunnan, China

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