Higher fasting glucose, triglycerides, resting pulse rate and high-sensitivity C reactive protein in adipose insulin-resistant but normal weight young Japanese women
机构：[1]Mukogawa Joshi Daigaku Eiyo Kagaku Kenkyujo, Nishinomiya, Hyogo, Japan[2]Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime, Japan[3]Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan[4]Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan[5]Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women's University, Kobe, Hyogo, Japan[6]Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan[7]Department of Advanced Epidemiology, Noncommunicable Disease (NCD) Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan[8]Department of Food Sciences and Nutrition, Mukogawa Joshi Daigaku, Nishinomiya, Hyogo, Japan[9]First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院内分泌一科内分泌科内科科室[10]Department of Medicine, Kohan Kakogawa Hospital, Kakogawa, Japan
IntroductionAdipose insulin-resistant but normal weight phenotype has not been reported and hence was characterized in young Japanese women.Research design and methodsBody composition, a broad range of cardiometabolic health and dietary intake were cross-sectionally measured in 166 normal weight young Japanese women. They were grouped into tertile of adipose tissue-insulin resistance (AT-IR) index (fasting insulinxfree fatty acids) and analyzed by analysis of variance and then Bonferroni's multiple comparison procedure.ResultsBody mass index averaged <21 kg/m(2) and waist <72 cm, and did not differ among three groups of women. Fasting glucose and triglycerides and homeostasis model assessment-insulin resistance were higher in the highest compared with the median and lowest AT-IR tertile. However, there was no difference in fat mass and distribution, high-density lipoprotein cholesterol and blood pressure. In addition, high-sensitivity C reactive protein (hsCRP) and resting pulse rate were higher as well. In multivariate logistic regression analyses, fasting glucose (OR: 1.10, 95% CI: 1.02 to 1.18, p=0.012), fasting triglycerides (OR: 1.04, 95% CI: 1.02 to 1.06, p<0.001), resting pulse rate (OR: 1.07, 95% CI: 1.03 to 1.11, p<0.001) and hsCRP (OR: 2.30, 95% CI: 1.01 to 5.2, p=0.04) were associated with the high AT-IR tertile.ConclusionsAdipose insulin-resistant but normal weight phenotype may be associated with increased sympathetic nervous system and low-grade systemic inflammation in addition to glucose and lipid dysmetabolism through mechanisms unrelated to adiposity in young Japanese women.
第一作者机构：[1]Mukogawa Joshi Daigaku Eiyo Kagaku Kenkyujo, Nishinomiya, Hyogo, Japan[2]Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime, Japan[3]Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan
通讯作者：
通讯机构：[1]Mukogawa Joshi Daigaku Eiyo Kagaku Kenkyujo, Nishinomiya, Hyogo, Japan[4]Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan[10]Department of Medicine, Kohan Kakogawa Hospital, Kakogawa, Japan
推荐引用方式(GB/T 7714)：
Minato-Inokawa Satomi,Honda Mari,Tsuboi-Kaji Ayaka,et al.Higher fasting glucose, triglycerides, resting pulse rate and high-sensitivity C reactive protein in adipose insulin-resistant but normal weight young Japanese women[J].BMJ OPEN DIABETES RESEARCH & CARE.2022,10(6):doi:10.1136/bmjdrc-2022-003013.
APA：
Minato-Inokawa, Satomi,Honda, Mari,Tsuboi-Kaji, Ayaka,Takeuchi, Mika,Kitaoka, Kaori...&Fukuo, Keisuke.(2022).Higher fasting glucose, triglycerides, resting pulse rate and high-sensitivity C reactive protein in adipose insulin-resistant but normal weight young Japanese women.BMJ OPEN DIABETES RESEARCH & CARE,10,(6)
MLA：
Minato-Inokawa, Satomi,et al."Higher fasting glucose, triglycerides, resting pulse rate and high-sensitivity C reactive protein in adipose insulin-resistant but normal weight young Japanese women".BMJ OPEN DIABETES RESEARCH & CARE 10..6(2022)
