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Pretreatment with 3-methyladenine ameliorated Pseudomonas aeruginosa-induced acute pneumonia by inhibiting cell death of neutrophils in a mouse infection model

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机构： [1]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China [2]The First People’s Hospital of Yunnan Province & Affiliated Hospital of Kunming University of Science and Technology, Kunming 650034, China [3]Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China [4]Department of Clinical Lab, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

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关键词： P aeruginosa 3-methyladenine Neutrophil Cell death Necroptosis

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Pseudomonas aeruginosa is one of the leading causes of nosocomial infections worldwide. Clinical isolates that are resistant to multiple antimicrobials make it intractable. The interactions between P. aeruginosa and host cell death have multiple effects on bacterial clearance and inflammation; however, the potential intervention effects remain to be defined. Herein, we demonstrated that intravenous administration of 3-methyladenine before, but not after, P. aeruginosa infection enhanced autophagy-independent survival, which was accompanied by a decrease in the bacterial load, alleviation of pathology and reduction in inflammatory cytokines, in an acute pneumonia mouse model. Interestingly, these beneficial effects were not dependent on neutrophil recruitment or phagocytosis, but on the enhanced killing capacity induced by inhibiting the cell death of 3-MA pretreated neutrophils. These findings demonstrate a novel protective role of 3-MA pretreatment in P. aeruginosa-induced acute pneumonia.Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.

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大类 | 3 区医学

小类 | 2 区病毒学 3 区微生物学

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出版当年[2023]版：

Q1 MICROBIOLOGY Q1 VIROLOGY

最新[2023]版：

Q1 MICROBIOLOGY Q1 VIROLOGY

影响因子： 4.5 最新[2023版] 3.3 最新五年平均 4.5 出版当年[2023版] 3.3 出版当年五年平均 4.1 出版前一年[2022版]

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第一作者机构： [1]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China

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Pretreatment with 3-methyladenine ameliorated Pseudomonas aeruginosa-induced acute pneumonia by inhibiting cell death of neutrophils in a mouse infection model

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