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Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study

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收录情况： ◇ SCIE

作者：
Zhang Yajuan[a,b] * ; Huang Chu-Chung[c,d] ; Zhao Jiajia[a] ; Liu Yuchen[a] ; Xia Mingrui[e,f,g] ; Wang Xiaoqin[h,i] ; Wei Dongtao[h,i] ; Chen Yuan[j] ; Liu Bangshan[k,l] ; Zheng Yanting[m] ; Wu Yankun[n] ; Chen Taolin[o,p] ; Cheng Yuqi[q] ; Xu Xiufeng[q] ; Gong Qiyong[o,p] ; Si Tianmei[n] ; Qiu Shijun[m] ; Cheng Jingliang[j] ; Tang Yanqing[r] ; Wang Fei[r] ; Qiu Jiang[h,i] ; Xie Peng[s,t,u] ; Li Lingjiang[k,l] ; He Yong[e,f,g,v] ; Lin Ching-Po[w] ; Zac Lo Chun-Yi[x] ; DIDA-Major Depressive Disorder Working Group[1] ;
机构： [a]Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China [b]School of Biomedical Engineering, ShanghaiTech University, Shanghai, China [c]Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China [d]Shanghai Changning Mental Health Center, Shanghai, China [e]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China [f]Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China [g]IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China [h]Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China [i]Department of Psychology, Southwest University, Chongqing, China [j]Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [k]Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China [l]Mental Health Institute of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Hunan Medical Center for Mental Health, Changsha, Hunan, China [m]Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [n]Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China [o]Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China [p]Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China [q]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China [r]Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China [s]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [t]NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [u]Chongqing Key Laboratory of Neurobiology, Chongqing, China [v]Institute for Brain Research, Beijing, China [w]Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan [x]Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, 32023, Taiwan
出处：
DOI： 10.1016/j.nicl.2023.103359
ISSN：

关键词： Serotonin Dorsal and median raphe nuclei Seed-based analysis Resting-state fMRI data Functional connectivity Multicenter

摘要：
Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources of most serotonergic neurons that project throughout the brain. Incorporating measurements of activity within the raphe nuclei into the analysis of connectivity characteristics may contribute to understanding how neurotransmitter synthesized centers are involved in thepathogenesisof MDD. Here, we analyzed the resting-state functional magnetic resonance imaging (RS-fMRI) dataset from 1,148 MDD patients and 1,079 healthy individuals recruited across nine centers. A seed-based analysis with the dorsal raphe and median raphe nuclei was performed to explore the functional connectivity (FC) alterations. Compared to controls, for dorsal raphe, the significantly decreased FC linking with the right precuneus and median cingulate cortex were found; for median raphe, the increased FC linking with right superior cerebellum (lobules V/VI) was found in MDD patients. In further exploratory analyzes, MDD-related connectivity alterations in dorsal and median raphe nuclei in different clinical factors remained highly similar to the main findings, indicating these abnormal connectivities are a disease-related alteration. Our study highlights a functional dysconnection pattern of raphe nuclei in MDD with multi-site big data. These findings help improve our understanding of the pathophysiology of depression and provide evidence of the theoretical foundation for the development of novel pharmacotherapies.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01), ZJ Lab, and Shanghai Center for Brain Science and Brain-Inspired Technology, the 111 Project (No.B18015), STI2030–Major Projects (2022ZD0213400), the National Natural Science Foundation of China (82201720; 82071998; 81671767; 82021004; 81620108016; 91432115; 81171286; 91232714; 31771231; 31271087; 81571331; 81271499; 81571311; 81920108019; 91649117; 81771344; 81471251; 81630031; 81621003; 81660237), Shanghai Science and Technology Innovation Plan (17JC1404105 and 17JC1404101), the Beijing Nova Program (Z191100001119023), Fundamental Research Funds for the Central Universities (2020NTST29), the National Key R&D Program of China (2018YFA0701400), the Changjiang Scholar Professorship Award (T2015027), the National Science and Technologic Program of China (2015BAI13B02), the National Basic Research Program of China (2013CB835100), the Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0520), the National High Tech Development Plan (863) (2015AA020513), the Medical Science and Technology Research Project of Henan Province (201701011), Science and Technology Plan Project of Guangzhou (2018-1002-SF-0442) and Guangzhou Key Laboratory (09002344)
语种：
外文
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中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 神经成像
JCR分区：
出版当年[2023]版：
Q2 NEUROIMAGING
最新[2023]版：
Q2 NEUROIMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [a]Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China [b]School of Biomedical Engineering, ShanghaiTech University, Shanghai, China
通讯作者：
通讯机构： [c]Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China [d]Shanghai Changning Mental Health Center, Shanghai, China
推荐引用方式(GB/T 7714)：
Zhang Yajuan,Huang Chu-Chung,Zhao Jiajia,et al.Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study[J].NEUROIMAGE-CLINICAL.2023,37:doi:10.1016/j.nicl.2023.103359.
APA：
Zhang Yajuan,Huang Chu-Chung,Zhao Jiajia,Liu Yuchen,Xia Mingrui...&DIDA-Major Depressive Disorder Working Group.(2023).Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study.NEUROIMAGE-CLINICAL,37,
MLA：
Zhang Yajuan,et al."Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study".NEUROIMAGE-CLINICAL 37.(2023)

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