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Differences in gray matter atrophy and functional connectivity between motor subtypes of Parkinson's disease

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机构： [1]The First People’s Hospital of Honghe Prefecture, Honghe 661100, China [2]The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [3]The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China

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关键词： Parkinson’s disease Gray matter volume Functional connectivity Postural instability/Gait difficulty Tremor-dominant Resting-state networks

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Parkinson's disease (PD) patients with postural gait abnormalities exhibit poorer motor function scores, more severe non-motor symptoms, faster cognitive function deterioration, and a less favorable response to drugs and surgery compared to PD patients with tremor. This discrepancy is believed to be associated with more pronounced gray matter atrophy and abnormal functional connectivity. To investigate the distinctive pathological mechanisms between PD subtypes, we examined gray matter volume (GMV) and functional connectivity in patients with Parkinson's disease presenting with postural instability/gait difficulty (PD-PIGD), patients with tremor-dominant Parkinson's disease (PD-TD), and healthy controls. Voxel-based morphometry (VBM) of T1-weighted images was conducted to compare GMV among 64 PD-PIGD patients, 44 PD-TD patients, and 32 controls. Subsequently, functional connectivity within regions showing reduced GMV was compared across the groups. We analyzed whether differences among the groups were associated with clinical characteristics and neuroimaging biomarkers using partial correlation and binary logistic regression. Our comparison between PD-PIGD and PD-TD patients revealed a link between PD-PIGD and more extensive frontotemporal atrophy, potentially indicating increased basal ganglia activity accompanied by decreased cerebellum activity. Furthermore, in addition to the smaller GMV in the left middle temporal gyrus, the increased functional connectivity between this brain region and the right caudate was also the independent risk factor for PD-PIGD. In addition, we compared brain network connectivity between the PIGD and TD subtypes, using an independent component analysis (ICA). We found that Compared to PD-TD, PD-PIGD patients showed an enhanced sensorimotor network (SMN) around the left supplementary motor area. These findings suggest that severe gray matter atrophy and abnormal functional connectivity and brain networks may serve as pathophysiological mechanisms distinguishing PD-PIGD patients from other subtypes.© 2024. The Author(s) under exclusive licence to Belgian Neurological Society.

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大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

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无

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Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2 最新[2023版] 2.2 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 2 出版前一年[2023版]

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第一作者机构： [1]The First People’s Hospital of Honghe Prefecture, Honghe 661100, China [2]The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

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