机构：[1]First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China[2]Imaging Center, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China医技科室医学影像中心CT室昆明医科大学附属第一医院云南省第一人民医院[3]Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China外科科室神经外科神经外一科（神经外科）昆明医科大学附属第一医院云南省第一人民医院[4]Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China外科科室泌尿外科昆明医科大学附属第一医院云南省第一人民医院[5]School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, China[6]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, KunmingInstitute of Zoology, Kunming, Yunnan, China
The SNP rs1006737 in CACNA1C gene has been significantly associated with psychiatric disorders (e.g., schizophrenia and bipolar disorder) in European populations. In Han Chinese, rs1006737 is also strongly associated with schizophrenia, although the effects of the psychosis risk SNP on related brain functions and structures in this population remain unclear. Here, we examined the association of rs1006737 with gray matter volume in a sample of 278 healthy Han Chinese. A whole-brain voxel-based morphometry (VBM) analysis revealed a significant association in the region around right superior occipital gyrus (family-wise error corrected, P=0.023). Our data provides initial evidence for the involvement of this psychosis genetic risk locus in brain structure variations in Chinese population, and calls for further investigations. (c) 2016 Wiley Periodicals, Inc.
基金：
Yunnan Provincial Science and Technology Department & Kunming Medical University applied basic research [2013FB141]
第一作者机构：[1]First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
共同第一作者：
通讯作者：
通讯机构：[*1]School of Chemistry and Chemical Engineering, Guangxi University, Guangxi, Nanning 530004, China[*2]Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan, Kunming 650223, China
推荐引用方式(GB/T 7714)：
Huang Liang,Mo Yin,Sun Xuejin,et al.The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population[J].AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS.2016,171(3):396-401.doi:10.1002/ajmg.b.32418.
APA：
Huang, Liang,Mo, Yin,Sun, Xuejin,Yu, Hualin,Li, Hao...&Li, Ming.(2016).The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,171,(3)
MLA：
Huang, Liang,et al."The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 171..3(2016):396-401
