机构：[1]Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.[2]Department of Otorhinolaryngological, Dezhou Second People's Hospital, Dezhou, China.[3]Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.[4]Department of Otolaryngology Division I, The First Affiliated Hospital of Kunming Medical University, Kunming, China外科科室耳鼻咽喉科昆明医科大学附属第一医院
Allergic rhinitis (AR) is a common atopic problem in which immune response to the environmental factors leads to clinical symptoms. Helicobacter pylori neutrophil-activating protein (HP-NAP) as a peptide attenuates Th2 response and stimulates Th1 activation and mucus adhesion promoting protein (MapA) as a cell-surface protein binds to mucus. This study evaluated the effect of HP-NAP and MapA conjugated with alumina nanoparticle on AR. HP-NAP and HP-NAP with MapA were conjugated to alumina nanoparticle and two separate nanoparticles were produced. The AR mice were treated with these and HP-NAP in peptide form. The AR symptoms, gene expression of mucus, levels of IL-33 and IL-4, and total and ovalbumin (OVA)-specific IgE levels were evaluated. Nasal rubbing, sneezing, gene expression of mucus, and IL-33 and IL-4 levels, and OVA-specific and total IgE were decreased in three treated groups compared to AR, and there was a significant decrease in the symptoms in AR-H-M-A group (P < 0.05) when compared to the other treated groups. HP-NAP has a controlling effect on AR, and in nanoparticle-conjugated form it can strongly attach to the airway's mucus via MapA. Therefore, cooperation of HP-NAP-alumina with MapA can produce an effective and applicable treatment for AR.
基金：
Doctoral Scientific Research Initiation Fund of Guangxi University of Traditional Chinese Medicine (2018BS021).
第一作者机构：[1]Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.
通讯作者：
通讯机构：[4]Department of Otolaryngology Division I, The First Affiliated Hospital of Kunming Medical University, Kunming, China[*1]Department of Otolaryngology Division I, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
推荐引用方式(GB/T 7714)：
Li Li,Wang Jing,Athari Seyyed Shamsadin,et al.Study on anti-inflammatory effect of peptides-conjugated alumina nanoparticle on allergic rhinitis mice model[J].ALLERGOLOGIA ET IMMUNOPATHOLOGIA.2023,51(3):111-116.doi:10.15586/aei.v51i3.819.
APA：
Li Li,Wang Jing,Athari Seyyed Shamsadin&Jiang Chao-Wu.(2023).Study on anti-inflammatory effect of peptides-conjugated alumina nanoparticle on allergic rhinitis mice model.ALLERGOLOGIA ET IMMUNOPATHOLOGIA,51,(3)
MLA：
Li Li,et al."Study on anti-inflammatory effect of peptides-conjugated alumina nanoparticle on allergic rhinitis mice model".ALLERGOLOGIA ET IMMUNOPATHOLOGIA 51..3(2023):111-116
