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Mesenchymal stem cell exosomes rich in miR-23b-3p affect the Wnt signaling pathway and promote neuronal autophagy to alleviate PD symptoms

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机构： [1]The Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. [2]Yunnan Provincial Clinical Research Center for Neurological Disease, Kunming, 650032, Yunnan. [3]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan.

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关键词： Parkinson's disease Neuronal cell autophagy Mesenchymal stem cells MiR-23b-3p Wnt signaling pathway

摘要：

This study aims to elucidate the role of miR-23b-3p in mesenchymal stem cell exosomes in regulating the Wnt signaling pathway to promote autophagy of neurons and alleviate Parkinson's disease (PD) symptoms. We generated rat and cellular PD models with 6-OHDA, treated them with mesenchymal stem cell exosomes rich in miR-23b-3p and determined the expression of α-syn and Wnt/β-catenin pathway and autophagy-related genes. In the plasma of PD patients, the levels of miR-23b-3p and the Wnt/β-catenin pathway-related genes β-catenin and DAT were low, while α-syn expression was high. In the PD cell model, miR-23b-3p was downregulated, the Wnt pathway was inhibited, α-syn was upregulated, neuron autophagy was inhibited, and the revitalization of the Wnt/β-catenin pathway could promote the autophagy of neurons. Coculture of miR-23b-3p-enriched exosomes with MN9D cells confirmed that miR-23b-3p-enriched exosomes could promote autophagy in MN9D cells in a PD cell model. Moreover, animal experiments confirmed the results of the cell experiments. Therefore, miR-23b-3p-enriched mesenchymal stem cell exosomes promote neuronal autophagy by regulating the Wnt signaling pathway, thus alleviating PD progression and providing an important basis for the clinical treatment of PD.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

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最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2023]版：

Q3 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES

影响因子： 2.5 最新[2023版] 2.5 最新五年平均 2.5 出版当年[2023版] 2.5 出版当年五年平均 2.5 出版前一年[2022版]

第一作者：

第一作者机构： [1]The Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. [2]Yunnan Provincial Clinical Research Center for Neurological Disease, Kunming, 650032, Yunnan.

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通讯作者：

通讯机构： [1]The Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. [2]Yunnan Provincial Clinical Research Center for Neurological Disease, Kunming, 650032, Yunnan. [3]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan.

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Mesenchymal stem cell exosomes rich in miR-23b-3p affect the Wnt signaling pathway and promote neuronal autophagy to alleviate PD symptoms

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