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Anti-inflammatory mechanisms of neutrophil membrane-coated nanoparticles without drug loading

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机构： [1]School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China [2]Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China [3]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming 650500, China [4]Department of Pharmacy, The First Affiliated Hospital of Army Medical University, Chongqing 400038, China [5]Chongqing Key Laboratory of Medicinal Chemistry & Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China

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关键词： Neutrophil membrane-coated nanoparticles Inflammation Cytokines Chemokines Macrophages Neutrophils

摘要：

Neutrophil membrane-coated nanoparticles (NM-NPs) are nanomedicines with traits of mimicking the surface properties and functions of neutrophils, which are the most abundant type of white blood cells in the human body. NM-NPs have been widely used as targeted drug delivery systems for various inflammatory diseases, but their intrinsic effects on inflammation are not fully characterized yet. This study found that NM-NPs could modulate inflammation by multiple mechanisms without drug loading. NM-NPs could inhibit the recruitment of neutrophils and macrophages to the inflamed site by capturing chemokines and blocking their adhesion to inflamed endothelial cells. After internalized by macrophages and other phagocytic cells, NM-NPs could alter their phenotype by phosphatidylserine and simultaneously degrade the sequestered and neutralized cytokines and chemokines by lysosomal degradation. Under these effects, NM-NPs exhibited significant anti-inflammatory effects on LPS-induced inflammatory liver injury in vivo without drug loading. Our study unveiled the anti-inflammatory effects and mechanisms of NM-NPs without drug loading, and provided new insights and evidence for understanding their biological effects and safety, as well as developing more effective and safe targeted drug delivery systems.Copyright © 2024 Elsevier B.V. All rights reserved.

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大类 | 1 区

医学

小类 | 1 区化学：综合 1 区药学

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出版当年[2024]版：

无

最新[2023]版：

Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY

影响因子： 10.5 最新[2023版] 10.6 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 10.5 出版前一年[2023版]

第一作者：

第一作者机构： [1]School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China [2]Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China

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通讯作者：

通讯机构： [3]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming 650500, China [5]Chongqing Key Laboratory of Medicinal Chemistry & Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China [*1]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming 650500, China.

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