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Functional connectivity between the habenula and posterior default mode network contributes to the response of the duloxetine effect in major depressive disorder

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收录情况： ◇ SCIE

作者：
Wu Yanru[1] ; Chu Zhaosong[1] ; Chen Xianyu[1] ; Zhu Yun[3] ; Xu Xiufeng[1,2] ; Shen Zonglin[1,2,*1] ;
机构： [1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University [2]Yunnan Clinical Research Center for Mental Disorders [3]Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
出处：
DOI： 10.1097/WNR.0000000000002019
ISSN：

关键词： antidepressant treatment default mode network habenula major depressive disorder

摘要：
This study aims to investigate the functional connectivity (FC) changes of the habenula (Hb) among patients with major depressive disorder (MDD) after 12 weeks of duloxetine treatment (MDD12). Patients who were diagnosed with MDD for the first time and were drug-naïve were recruited at baseline as cases. Healthy controls (HCs) matched for sex, age, and education level were also recruited at the same time. At baseline, all participants underwent resting-state functional MRI. FC analyses were performed using the Hb seed region of interest, and three groups including HCs, MDD group and MDD12 group were compared using whole-brain voxel-wise comparisons. Compared to the HCs, the MDD group had decreased FC between the Hb and the right anterior cingulate cortex at baseline. Compared to the HCs, the FC between the Hb and the left medial superior frontal gyrus decreased in the MDD12 group. Additionally, the FC between the left precuneus, bilateral cuneus and Hb increased in the MDD12 group than that in the MDD group. No significant correlation was found between HDRS-17 and the FC between the Hb, bilateral cuneus, and the left precuneus in the MDD12 group. Our study suggests that the FC between the post-default mode network and Hb may be the treatment mechanism of duloxetine and the treatment mechanisms and the pathogenesis of depression may be independent of each other.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

基金：
This study was funded by the National Natural Science Foundation of China (81660237, 82260277). Yunnan Fundamental Research Projects (202301AT070126). Yunnan Health Training Project of High Level Talents (H-2018090). Yunnan Clinical Research Center for Mental Disorders (202102AA100058).
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外文
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大类 | 4 区 医学
小类 | 4 区 神经科学
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出版当年[2024]版：
无
最新[2023]版：
Q4 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University
共同第一作者：
通讯作者：
通讯机构： [1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University [2]Yunnan Clinical Research Center for Mental Disorders [*1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Yunnan, China
推荐引用方式(GB/T 7714)：
Wu Yanru,Chu Zhaosong,Chen Xianyu,et al.Functional connectivity between the habenula and posterior default mode network contributes to the response of the duloxetine effect in major depressive disorder[J].NEUROREPORT.2024,35(6):380-386.doi:10.1097/WNR.0000000000002019.
APA：
Wu Yanru,Chu Zhaosong,Chen Xianyu,Zhu Yun,Xu Xiufeng&Shen Zonglin.(2024).Functional connectivity between the habenula and posterior default mode network contributes to the response of the duloxetine effect in major depressive disorder.NEUROREPORT,35,(6)
MLA：
Wu Yanru,et al."Functional connectivity between the habenula and posterior default mode network contributes to the response of the duloxetine effect in major depressive disorder".NEUROREPORT 35..6(2024):380-386

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