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Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project.

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机构： [a]National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University. Changsha, Hunan 410011, China [b]Department of Radiology, The Second Xiangya Hospital of Central South University. Changsha, Hunan 410011, China [c]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China [d]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China [e]Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute of Psychology, Chinese Academy of Sciences, Beijing, China [f]International Big-Data Center for Depression Research, Institute of Psychology, Chinese Academy of Sciences, Beijing, China [g]Anhui Medical University, Hefei, Anhui, China [h]Beijing Anding Hospital, Capital Medical University, Beijing 100054, China [i]The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China [j]Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China [k]First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650221, China [l]Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China [m]Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China [n]Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China [o]Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China [p]Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210096, China [q]Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [r]Mental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan, China [s]Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China [t]The Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha, Hunan 410008, China [u]Faculty of Psychology, Southwest University, Chongqing 400716, China [v]Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou, Zhejiang 311121, China [w]Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China [x]National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China [y]Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China [z]Xi’an Central Hospital, Xi’an, Shaanxi, China [aa]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, China [ab]Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China [ac]Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China ad Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China [ae]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [af]The First Affiliated Hospital of Xi’an Jiaotong University, Shaanxi 710061, China [ag]First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030006, China [ah]Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China [ai]Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang 311121, China

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关键词： Major depressive disorder hemispheric asymmetry parameter of asymmetry fMRI Abbreviations ACC Anterior cingulate gyrus DLPFC Dorsolateral prefrontal cortex DMN Default mode network DPARSF Data Processing Assistant for Resting- State fMRI DSM Diagnosic and Statistical Manual of Mental Disorders EEG Electroencephalographic FC Functional connectivity FDR False discovery rate FEDN First-episode drug-naive FEF Frontal eye fields fMRI Functional magnetic resonance imaging HAMD Hamilton Depression Rating Scale HC Healthy control IFG Inferior frontal gyrus IPL Inferior parietal lobule IPS/SPL Intraparietal sulcus/superior parietal lobule LMM Linear mixed model MDD Major depressive disorder MFG Middle frontal gyrus MTG Middle temporal gyrus PAS Parameter of asymmetry PCC Posterior cingulate cortex PET Positron emission tomography ROIs Regions of interest rs-fMRI Resting-state fMRI rTMS repetitive transcranial magnetic stimulation STS Superior temporal sulcus VMHC Voxel-mirrored homotopic connectivity

摘要：

Functional specialization is a feature of human brain for understanding the pathophysiology of major depressive disorder (MDD). The degree of human specialization refers to within and cross hemispheric interactions. However, most previous studies only focused on interhemispheric connectivity in MDD, and the results varied across studies. Hence, brain functional connectivity asymmetry in MDD should be further studied. Resting-state fMRI data of 753 patients with MDD and 451 healthy controls were provided by REST-meta-MDD Project. Twenty-five project contributors preprocessed their data locally with the Data Processing Assistant State fMRI software and shared final indices. The parameter of asymmetry (PAS), a novel voxel-based whole-brain quantitative measure that reflects inter- and intrahemispheric asymmetry, was reported. We also examined the effects of age, sex and clinical variables (including symptom severity, illness duration and three depressive phenotypes). Compared with healthy controls, patients with MDD showed increased PAS scores (decreased hemispheric specialization) in most of the areas of default mode network, control network, attention network and some regions in the cerebellum and visual cortex. Demographic characteristics and clinical variables have significant effects on these abnormalities. Although a large sample size could improve statistical power, future independent efforts are needed to confirm our results. Our results highlight the idea that many brain networks contribute to broad clinical pathophysiology of MDD, and indicate that a lateralized, efficient and economical brain information processing system is disrupted in MDD. These findings may help comprehensively clarify the pathophysiology of MDD in a new hemispheric specialization perspective. Copyright © 2021 Elsevier B.V. All rights reserved.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区精神病学 2 区临床神经病学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区临床神经病学 2 区精神病学

JCR分区：

出版当年[2021]版：

Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY

影响因子： 4.9 最新[2023版] 5.4 最新五年平均 6.533 出版当年[2021版] 6.569 出版当年五年平均 4.839 出版前一年[2020版] 6.6 出版后一年[2022版]

第一作者：

第一作者机构： [a]National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University. Changsha, Hunan 410011, China

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通讯作者：

通讯机构： [a]National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University. Changsha, Hunan 410011, China [*1]Department of Psychiatry, The Second Xiangya Hospital of Central South University. Changsha, Hunan 410011, China

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Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project.

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