机构：[1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China内科科室精神科昆明医科大学附属第一医院[2]Department of Psychiatry, The First Hospital of Jiaxing or The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China[3]Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-senUniversity, Zhuhai, Guangdong, China[4]Research Center of Molecular Imaging, Fifth Affiliated Hospital of Sun Yat-senUniversity, Zhuhai, Guangdong, China[5]Department of Rheumatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China昆明医科大学附属第一医院风湿免疫科内科科室[6]Fifth People's Hospital of Zigong City, Zigong, Sichuan, China[7]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China[8]Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China[9]Anhui Medical University, Hefei, Anhui, China[10]Beijing Anding Hospital, Capital Medical University, Beijing, China[11]Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China重庆医科大学附属第一医院[12]The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China[13]Department of Psychiatry, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China[14]Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China[15]Department of Psychiatry, First Affiliated Hospital, China,Medical University, Shenyang, Liaoning, China[16]Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China[17]Department of Radiology, Huaxi MR Research Center, West China,Hospital of Sichuan University, Chengdu, Sichuan, China[18]Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China,Hospital of Sichuan University, Chengdu, Sichuan, China[19]Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China[20]Mental Health Center, West China,Hospital, Sichuan University Chengdu, Sichuan, China[21]Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China[22]Faculty of Psychology, Southwest University, Chongqing, China[23]Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China浙江大学医学院附属第一医院[24]National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China[25]Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China[26]Xi'an Central Hospital, Xi'an, Shaanxi, China[27]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China[28]Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China[29]Institute of Neuroscience, Chongqing Medical University, Chongqing, China[30]Chongqing Key Laboratory of Neurobiology, Chongqing, China[31]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China重庆医科大学附属第一医院[32]The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China[33]First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Background Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < 0.002, z = -7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction in MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
基金：
National Natural Science Foundation of China [82060259, 81760296, 81660237]; Medical Leader Foundation of Yunnan Province [L2019011, L2019004]; Famous Doctors Project of Yunnan Province Plan [YNWR-MY-2018-040, YNWR-MY-2018-041]; Applied Basic Key Project of Yunnan Provincial Department of Science and Technology--Kunming Medical University Joint Foundation [2017FE468(-176)]
第一作者机构：[1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China[2]Department of Psychiatry, The First Hospital of Jiaxing or The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China
通讯作者：
通讯机构：[1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China[*1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming City, Yunnan 650032, China.
推荐引用方式(GB/T 7714)：
Ke Deng,Ji-Hui Yue,Jian Xu,et al.Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China[J].BIPOLAR DISORDERS.2022,24(4):400-411.doi:10.1111/bdi.13139.
APA：
Ke Deng,Ji-Hui Yue,Jian Xu,Ping-Ping Ma,Xiao Chen...&Yu-Qi Cheng.(2022).Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.BIPOLAR DISORDERS,24,(4)
MLA：
Ke Deng,et al."Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China".BIPOLAR DISORDERS 24..4(2022):400-411
