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The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder

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资源类型：
Pubmed体系：
作者：
Chen Xiao[1,2,3,4] * ; Lu Bin[2,3] ; Li Hui-Xian[2,3] ; Li Xue-Ying[1,2,3,4,5,6] ; Wang Yu-Wei[2,3] ; Castellanos Francisco Xavier[7,8] ; Cao Li-Ping[9] ; Chen Ning-Xuan[10] ; Chen Wei[11] ; Cheng Yu-Qi[12] ; Cui Shi-Xian[2,5,6] ; Deng Zhao-Yu[2,3] ; Fang Yi-Ru[13] ; Gong Qi-Yong[14,15] ; Guo Wen-Bin[16] ; Hu Zheng-Jia-Yi[2,3] ; Kuang Li[17] ; Li Bao-Juan[18] ; Li Le[19] ; Li Tao[20,21] ; Lian Tao[1,2,3] ; Liao Yi-Fan[1,2,3] ; Liu Yan-Song[22] ; Liu Zhe-Ning[16] ; Lu Jian-Ping[23] ; Luo Qing-Hua[17] ; Meng Hua-Qing[17] ; Peng Dai-Hui[13] ; Qiu Jiang[24] ; Shen Yue-Di[25] ; Si Tian-Mei[26] ; Tang Yan-Qing[27] ; Wang Chuan-Yue[28] ; Wang Fei[27,29] ; Wang Hua-Ning[18] ; Wang Kai[30] ; Wang Xiang[16] ; Wang Ying[31] ; Wang Zi-Han[2,3] ; Wu Xiao-Ping[32] ; Xie Chun-Ming[33] ; Xie Guang-Rong[16] ; Xie Peng[34,35,36] ; Xu Xiu-Feng[12] ; Yang Hong[37] ; Yang Jian[35] ; Yao Shu-Qiao[16] ; Yu Yong-Qiang[38] ; Yuan Yong-Gui[39] ; Zhang Ke-Rang[40] ; Zhang Wei[41] ; Zhang Zhi-Jun[33] ; Zhu Jun-Juan[42] ; Zuo Xi-Nian[43,44] ; Zhao Jing-Ping[16] ; Zang Yu-Feng[45,46] ; Yan Chao-Gan[1,2,3,4,5,6] ;
机构： [1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. [2]International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China. [3]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. [4]Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China. [5]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China. [6]Sino-Danish Center for Education and Research, Graduate University of Chinese Academy of Sciences, Beijing 101408, China. [7]Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY 10016, USA. [8]Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, NY 10962, USA. [9]Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China. [10]Capital Normal University, Beijing 100089, China. [11]Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, Zhejiang, China. [12]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China. [13]Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China. [14]Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China. [15]Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan 610052, China. [16]Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China. [17]Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China. [18]Xijing Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China. [19]Center for Cognitive Science of Language, Beijing Language and Culture University, Beijing 100083, China. [20]Affiliated Mental Health Center &amp [21] Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310063, China. [21]Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China. [22]Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu 215003, China. [23]Shenzhen Kangning Hospital, Shenzhen, Guangzhou 518020, China. [24]Faculty of Psychology, Southwest University, Chongqing 400715, China. [25]Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou, Zhejiang 311121, China. [26]National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp [28] Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China. [27]Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110122, China. [28]Beijing Anding Hospital, Capital Medical University, Beijing 100120, China. [29]Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210024, China. [30]Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China. [31]The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 250024, China. [32]Xi'an Central Hospital, Xi'an, Shaanxi 710004, China. [33]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, China. [34]Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. [35]Chongqing Key Laboratory of Neurobiology, Chongqing 400000, China. [36]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China. [37]Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China. [38]The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China. [39]Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China. [40]First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China. [41]West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China. [42]Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. [43]Developmental Population Neuroscience Research Center, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100091, China. [44]National Basic Science Data Center, Beijing 100038, China. [45]Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310018, China. [46]Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang 310000, China.
出处：
DOI： 10.1093/psyrad/kkac005

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

摘要：
Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder (MDD), reproducible findings are lacking, probably reflecting mostly small sample sizes and heterogeneity in analytic approaches. To address these issues, the Depression Imaging REsearch ConsorTium (DIRECT) was launched. The REST-meta-MDD project, pooling 2428 functional brain images processed with a standardized pipeline across all participating sites, has been the first effort from DIRECT. In this review, we present an overview of the motivations, rationale, and principal findings of the studies so far from the REST-meta-MDD project. Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network, in whole-brain topological properties, in dynamic features, and in functional lateralization. These well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven research. Following these fruitful explorations, DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations. A state-of-the-art, surface-based preprocessing pipeline has also been introduced to improve sensitivity. Functional images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diagnosis boundaries. In addition, large-scale longitudinal studies targeting brain network alterations following antidepressant treatment, aggregation of diffusion tensor images, and the development of functional magnetic resonance imaging-guided neuromodulation approaches are underway. Through these endeavours, we hope to accelerate the translation of functional neuroimaging findings to clinical use, such as evaluating longitudinal effects of antidepressant medications and developing individualized neuromodulation targets, while building an open repository for the scientific community.© The Author(s) 2022. Published by Oxford University Press on behalf of West China School of Medicine/West China Hospital (WCSM/WCH) of Sichuan University.

基金：
National Key R&D Program of China no. 2017YFC1309902; the National Natural Science Foundation of China grant numbers 82122035, 81671774, and 81630031; the 13th Five-year Informatization Plan of Chinese Academy of Sciences grant no. XXH13505; the Key Research Program of the Chinese Academy of Sciences no. ZDBS-SSW-JSC006; Beijing Nova Program of Science and Technology no.Z191100001119104; and the China National Postdoctoral Program for Innovative Talents no. BX20200360.
语种：
外文
PubmedID：
第一作者：
第一作者机构： [1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. [2]International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China. [3]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. [4]Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
通讯作者：
通讯机构： [1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. [2]International Big-Data Center for Depression Research, Chinese Academy of Sciences, Beijing 100101, China. [3]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. [4]Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China. [5]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China. [6]Sino-Danish Center for Education and Research, Graduate University of Chinese Academy of Sciences, Beijing 101408, China.
推荐引用方式(GB/T 7714)：
Chen Xiao,Lu Bin,Li Hui-Xian,et al.The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder[J].Psychoradiology.2022,2(1):32-42.doi:10.1093/psyrad/kkac005.
APA：
Chen Xiao,Lu Bin,Li Hui-Xian,Li Xue-Ying,Wang Yu-Wei...&Yan Chao-Gan.(2022).The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder.Psychoradiology,2,(1)
MLA：
Chen Xiao,et al."The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder".Psychoradiology 2..1(2022):32-42

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