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A chitosan-camouflaged nanomedicine triggered by hierarchically stimuli to release drug for multimodal imaging-guided chemotherapy of breast cancer

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Pei[1] ; Peng Zhi[2] ; Zhang Yanyan[3] ; Zhang Xuejing[3] ; Chen Xia[3] ; Li Fan[4] ; Chen Bo[4] ; Niu Shiwei[4] ; Du Kaili[5] ; Zhu Li-Min[3] ;
机构： [1]Department of Radiation Oncology, Cancer Institute, the First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, PR China [2]Department of Orthopedic Surgery, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, PR China [3]College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, PR China [4]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming 650500, PR China [5]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, PR China
出处：
DOI： 10.1016/j.carbpol.2024.122073
ISSN：

关键词： Chitosan Paclitaxel delivery Hierarchically stimuli trigger Multimodal imaging Theranostic Malignant breast cancer

摘要：
Breast cancer remains one of the most intractable diseases, especially the malignant form of metastasis, with which the cancer cells are hard to track and eliminate. Herein, the common known carbohydrate polymer chitosan (CS) was innovatively used as a shelter for the potent tumor-killing agent. The designed nanoparticles (NPs) not only enhance the solubility of hydrophobic paclitaxel (PTX), but also provide a "hide" effect for cytotoxic PTX in physiological condition. Moreover, coupled with the photothermal (PTT) properties of MoS2, results in a potent chemo/PTT platform. The MoS2@PTX-CS-K237 NPs have a uniform size (135 ± 17 nm), potent photothermal properties (η = 31.5 %), and environment-responsive (low pH, hypoxia) and near infrared (NIR) laser irradiation-triggered PTX release. Through a series of in vitro and in vivo experiments, the MoS2@PTX-CS-K237 showed high affinity and specificity for breast cancer cells, impressive tumor killing capacity, as well as the effective inhibitory effect of metastasis. Benefit from the unique optical properties of MoS2, this multifunctional nanomedicine also exhibited favorable thermal/PA/CT multimodality imaging effect on tumor-bearing mice. The system developed in this work represents the advanced design concept of hierarchical stimulus responsive drug release, and merits further investigation as a potential nanotheranostic platform for clinical translation.Copyright © 2024 Elsevier Ltd. All rights reserved.

基金：
Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Project on Applied Basic Research (202201AY070001-029/ 202201AY070001- 030/202201AY070001-054), Yunnan Health Training Project of High Level Talents (Grant Number H-2019011), grants 22520710400, 20DZ2254900 and 21WZ2501300 from the Science and Technology Commission of Shanghai Municipality, the Major Science and Technology Project of Yunnan Provincial Department of Science and Technology, Yunnan Provincial Orthopedic and Sports Rehabilitation Clinical Medicine Research Center (Grant Number 202102AA310068) and the Yunnan Revitalization Talent Support Program.
语种：
外文
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中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 CHEMISTRY, APPLIED Q1 CHEMISTRY, ORGANIC Q1 POLYMER SCIENCE

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Radiation Oncology, Cancer Institute, the First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Pei,Peng Zhi,Zhang Yanyan,et al.A chitosan-camouflaged nanomedicine triggered by hierarchically stimuli to release drug for multimodal imaging-guided chemotherapy of breast cancer[J].Carbohydrate Polymers.2024,335:122073.doi:10.1016/j.carbpol.2024.122073.
APA：
Wang Pei,Peng Zhi,Zhang Yanyan,Zhang Xuejing,Chen Xia...&Zhu Li-Min.(2024).A chitosan-camouflaged nanomedicine triggered by hierarchically stimuli to release drug for multimodal imaging-guided chemotherapy of breast cancer.Carbohydrate Polymers,335,
MLA：
Wang Pei,et al."A chitosan-camouflaged nanomedicine triggered by hierarchically stimuli to release drug for multimodal imaging-guided chemotherapy of breast cancer".Carbohydrate Polymers 335.(2024):122073

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