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Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration.

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收录情况： ◇ SCIE ◇ 卓越：高起点新刊

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机构： [1]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming,650500, China [2]Department of Stomatology, The First People’s Hospital of Yunnan Province, Kunming, 650032, China [3]Department of Neurology, The First Affiliated Hospital, Kunming Medical University, Kunming, 650000, China [4]Yunnan Key Laboratory of Digital Orthopaedics, Department of Orthopaedics, The First People’s Hospital of Yunnan Province, Kunming, 650032, China [5]Department of Endocrinology, The Third People’s Hospital of Yunnan Province, Kunming, 650011, China

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关键词： Anti-inflammation n-HA/Res/CS microsphere Osteo-differentiation Osteoporotic bone regeneration

摘要：

The development of functional materials for osteoporosis is ultimately required for bone remodeling. However, grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone formation. In this work, nano-hydroxyapatite (n-HA)/resveratrol (Res)/chitosan (CS) composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of Res. Study of in vitro release confirmed the feasibility of n-HA/Res/CS microspheres for controlled Res release. Notably, microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TNF-α, IL-1β and iNOS in RAW264.7 cells in a dose dependent manner. Further, enhanced adhesion and proliferation of BMSCs seeded onto microspheres demonstrated that composite microspheres were conducive to cell growth. The ability to enhance osteo-differentiation was supported by up-regulation of Runx2, ALP, Col-1 and OCN, and substantial mineralization in osteogenic medium. When implanted into bone defects in the osteoporotic rat femoral condyles, enhanced entochondrostosis and bone regeneration suggested that the n-HA/Res/CS composite microspheres were more favorable for impaired fracture healing. The results indicated that optimized n-HA/Res/CS composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment. © 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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出版当年[2022]版：

大类 | 1 区

工程技术

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

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出版当年[2021]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

最新[2023]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 18 最新[2023版] 18.2 最新五年平均 16.874 出版当年[2021版] 17.363 出版当年五年平均 14.593 出版前一年[2020版] 18.9 出版后一年[2022版]

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第一作者机构： [1]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming,650500, China

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通讯机构： [*1]Department of Endocrinology, The Third People’s Hospital of Yunnan Province, Kunming, 650011, China

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