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Inhibition of respiratory syncytial virus replication and suppression of RSV-induced airway inflammation in neonatal rats by colchicine

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收录情况： ◇ SCIE

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机构： [1]Department of Respiratory Medicine, The Third People’s Hospital of Kunming City, Kunming 650041, Yunnan, China [2]Department of Urinary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China [3]Department of Cardiovascular, The Third People’s Hospital of Kunming City, Kunming 650041, Yunnan, China

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关键词： Bronchiolitis Pneumonia Anti-oxidant Inflammation Microtubule

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The present study investigated the role of colchicine in the treatment of RSV infection. Treatment of BEAS-2B cells following RSV infection with colchicine caused a significant decrease in the number of viral plaques. In RSV-infected BEAS-2B cells' treatment with colchicine leads to a significant up-regulation of both IFN-beta 1 and RIG-I genes. The levels of interleukin, NO, and MDA were suppressed in BEAS-2B cells infected with RSV by colchicine. The phosphorylation of Stat3, COX-2, and p38 was also suppressed significantly by colchicine. The phosphorylation of IkB alpha was promoted in RSV-infected BEAS-2B cells' oncolchicine treatment. In neonatal rats, replication of RSV was inhibited significantly by colchicine treatment which was evident by suppression of RSV-L gene expression. A significant decrease in the level of IL-6 and TNF-alpha was caused in neonatal rat BALF by colchicine treatment. The production of MDA, NO and MPO in the neonatal rat BALF was suppressed markedly by colchicine treatment. Treatment of the neonatal rats infected by RSV with colchicine suppressed the release of I kappa B alpha and COX-2 in the pulmonary epithelial cells. Colchicine treatment of the neonatal rats promoted the expression of IFN-alpha and IFN-beta 1. In summary, the current study showed that colchicine inhibited RSV infection in neonatal rats through regulation of anti-oxidative factor production. The expression of IFN-beta 1 and RIG-I genes was also up-regulated in the RSV-infected alveolar epithelial cells by treatment with colchicine. Therefore, colchicine may be developed as the therapeutic agent for the treatment of RSV infection.

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出版当年[2020]版：

大类 | 4 区生物

小类 | 4 区生物工程与应用微生物

最新[2023]版：

大类 | 4 区生物学

小类 | 4 区生物工程与应用微生物

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出版当年[2019]版：

Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

最新[2023]版：

Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

影响因子： 2.6 最新[2023版] 2.9 最新五年平均 1.798 出版当年[2019版] 2.389 出版当年五年平均 1.786 出版前一年[2018版] 2.406 出版后一年[2020版]

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第一作者机构： [1]Department of Respiratory Medicine, The Third People’s Hospital of Kunming City, Kunming 650041, Yunnan, China

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