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Exploring the diagnostic value of endothelial cell and angiogenesis-related genes in Hashimoto's thyroiditis Based on transcriptomics and single cell RNA sequencing

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收录情况： ◇ SCIE

作者：
Li Yihang[1,3] ; Lu Xiaokai[2] ; Cao Weihan[1] ; Liu Nianqiu[4] ; Jin Xin[5] ; Li Yuting[1] ; Tang Shiying[1] ; Tao Ling[3] ; Zhu Qian[3] ; Zhu Gaohong[6] ; Liang Hongmin[1] ;
机构： [1]Department of Ultrasound, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, PR China [2]Department of Ultrasound, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, PR China [3]Kunming Medical University, Kunming, Yunnan, 650000, PR China [4]Department of Breast Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Center, Kunming, Yunnan 650000, PR China [5]Department of Ultrasound, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology [6]Department of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, PR China
出处：
DOI： 10.1016/j.abb.2024.110013
ISSN：

关键词： Hashimoto’s thyroiditis Endothelial cell-related genes Angiogenesis-related genes Diagnosis Single-cell RNA sequencing

摘要：
(1) BACKGROUND: Hashimoto's thyroiditis (HT) can cause angiogenesis in the thyroid gland. However, the molecular mechanism of endothelial cells and angiogenesis related genes (ARGs) has not been extensively studied in HT. (2) METHODS: The HRA001684, GSE29315 and GSE163203 datasets were included in this study. Using single-cell analysis, weighted gene co-expression network analysis (WGCNA), functional enrichment analysis, machine learning algorithms and expression analysis for exploration. And receiver operator characteristic (ROC) curves was draw. Gene set enrichment analysis (GSEA) was utilized to investigate the biological function of the biomarkers. Meanwhile, we investigated into the relationship between biomarkers and different types of immune cells. Additionally, the expression of biomarkers in the TCGA-TC dataset was examined and the mRNA-drug interaction network was constructed. (3) RESULTS: We found 14 cell subtypes were obtained in HT samples after single-cell analysis. A total of 5 biomarkers (CD52, CD74, CD79A, HLA-B and RGS1) were derived, and they had excellent diagnostic performance. Then, 27 drugs targeting biomarkers were predicted. The expression analysis showed that CD74 and HLA-B were significantly up-regulated in HT samples. (4) CONCLUSION: In this study, 5 biomarkers (CD52, CD74, CD79A, HLA-B and RGS1) were screened and their expressions in endothelial cells was compared to offer a new reference for the recognition and management of HT.Copyright © 2024. Published by Elsevier Inc.

基金：
Yunnan Provincial Science and Technology Department Science and Technology Project, The First Affiliated Hospital of Kunming Medical University (grant no. 202001AY070001-212 and 202301AY070001-009), scientific research foundation of Yunnan Education Department (No. 2023Y065).
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外文
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出版当年[2025]版：
无
最新[2023]版：
大类 | 3 区 生物学
小类 | 2 区 生物物理 3 区 生化与分子生物学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Ultrasound, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650000, PR China [3]Kunming Medical University, Kunming, Yunnan, 650000, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yihang,Lu Xiaokai,Cao Weihan,et al.Exploring the diagnostic value of endothelial cell and angiogenesis-related genes in Hashimoto's thyroiditis Based on transcriptomics and single cell RNA sequencing[J].ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.2024,757:110013.doi:10.1016/j.abb.2024.110013.
APA：
Li Yihang,Lu Xiaokai,Cao Weihan,Liu Nianqiu,Jin Xin...&Liang Hongmin.(2024).Exploring the diagnostic value of endothelial cell and angiogenesis-related genes in Hashimoto's thyroiditis Based on transcriptomics and single cell RNA sequencing.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,757,
MLA：
Li Yihang,et al."Exploring the diagnostic value of endothelial cell and angiogenesis-related genes in Hashimoto's thyroiditis Based on transcriptomics and single cell RNA sequencing".ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 757.(2024):110013

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