机构:[1]Kunming Med Univ,Affiliated Hosp 1,Dept Nephrol,295 Xichang Rd,Kunming,Peoples R China昆明医科大学附属第一医院内科科室肾脏内科[2]Kunming Med Univ,Affiliated Hosp 1,Organ Transplantat Ctr,Kunming,Peoples R China医技科室医学影像中心CT室昆明医科大学附属第一医院[3]Kunming Med Univ,Affiliated Hosp 1,Dept Pulm & Crit Care Med,295 Xichang Rd,Kunming,Peoples R China昆明医科大学附属第一医院[4]Xishuangbanna Dai Autonomous Prefecture Peoples Ho, Dept Nephrol, Xishuangbanna, Peoples R China[5]Yunnan Prov Clin Res Ctr Chron Kidney Dis, 295 Xichang Rd, Kunming, Peoples R China
GDF-15 is an essential member of the transforming growth factor -beta superfamily. Its functions mainly involve in tissue injury, inflammation, fibrosis, regulation of appetite and weight, development of tumor, and cardiovascular disease. GDF-15 is involved in various signaling pathways, such as MAPK pathway, PI3K/AKT pathway, STAT3 pathway, RET pathway, and SMAD pathway. In addition, several factors such as p53, ROS, and TNF-alpha participate the regulation of GDF-15. However, the specific mechanism of these factors regulating GDF-15 is still unclear and more research is needed to explore them. GDF-15 mainly improves the function of kidneys in CKD and plays an important role in the prediction of CKD progression and cardiovascular complications. In addition, the role of GDF-15 in the kidney may be related to the SMAD and MAPK pathways. However, the specific mechanism of these pathways remains unclear. Accordingly, more research on the specific mechanism of GDF-15 affecting kidney disease is needed in the future. In conclusion, GDF-15 may be a therapeutic target for kidney disease.
基金:
Yunnan Major Scientific and Technological Project [202102AA100060]; Yunnan Revitalization Talent Support Program; National Natural Science Foundation of China [82160007]; Yunnan Provincial Science and Technology Department [2019FE001 (-58), 202201AY070001 (-074)]; Yunnan Province young and middle-aged academic and technical leaders reserve talent project [202305AC160017]; 535 Talent Project of First Affiliated Hospital of Kunming Medical University ( [2023535D12]; Student Innovation Fund project of Kunming Medical University [2022JXD212, 2022JXD227]
第一作者机构:[1]Kunming Med Univ,Affiliated Hosp 1,Dept Nephrol,295 Xichang Rd,Kunming,Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Kunming Med Univ,Affiliated Hosp 1,Dept Nephrol,295 Xichang Rd,Kunming,Peoples R China[5]Yunnan Prov Clin Res Ctr Chron Kidney Dis, 295 Xichang Rd, Kunming, Peoples R China
推荐引用方式(GB/T 7714):
Tang Yifang,Liu Tao,Sun Shibo,et al.Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease[J].JOURNAL OF INFLAMMATION RESEARCH.2024,17:2861-2871.doi:10.2147/JIR.S451398.
APA:
Tang, Yifang,Liu, Tao,Sun, Shibo,Peng, Youbo,Huang, Xiaoxiao...&Zhou, Zhu.(2024).Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease.JOURNAL OF INFLAMMATION RESEARCH,17,
MLA:
Tang, Yifang,et al."Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease".JOURNAL OF INFLAMMATION RESEARCH 17.(2024):2861-2871