Objective To explore the relationship between rs1410996 polymorphism of CFH gene and essential hypertension (EH) in the Yunnan Han population. Methods rs1410996 of CFH gene was genotyped based on the collected clinical phenotypes of the EH patients (n = 520) and healthy people (n = 494). Results On the genotype model and dominance model, there was no relationship between rs1410996 of CFH gene and EH after adjustment (P > 0.05). On the dominance model of male EH patients, the pulse pressure (PP) level of CC genotype carriers was higher than that of (CT + TT) genotype carriers after adjustment (P < 0.05). Conclusion rs1410996 of CFH gene has no correlation with the genetic susceptibility to EH in the Yunnan Han population, but it is related to the PP level in male patients.
基金：
Yunnan Provincial Reserve Training Program for Young and Middle-aged Academic and Technical Leaders (202005AC160053).
第一作者机构：[1]Nanjing Univ, Yancheng Peoples Hosp 1, Dept Cardiovasc Med, Affiliated Hosp,Med Sch, Yancheng, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Chengzhen,Guo Li,Yuan Yong,et al.Relationship between rs1410996 polymorphism of CFH gene and essential hypertension patients of Han from Yunnan Province[J].MOLECULAR BIOLOGY REPORTS.2024,51(1):doi:10.1007/s11033-024-09819-5.
APA：
Zhu, Chengzhen,Guo, Li,Yuan, Yong&Guo, Hao.(2024).Relationship between rs1410996 polymorphism of CFH gene and essential hypertension patients of Han from Yunnan Province.MOLECULAR BIOLOGY REPORTS,51,(1)
MLA：
Zhu, Chengzhen,et al."Relationship between rs1410996 polymorphism of CFH gene and essential hypertension patients of Han from Yunnan Province".MOLECULAR BIOLOGY REPORTS 51..1(2024)
