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Chinese expert consensus on allergen component resolved diagnosis

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机构： [1]Department of Clinical Laboratory, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. [2]Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [3]Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China. [4]Clinical Research Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. [5]Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. [6]Institute of Immunology, School of Medicine, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China. [7]Department of Allergy, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China. [8]Department of Chinese Journal of Preventive Medicine, Beijing, China. [9]Allergy Center, Department of Otolaryngology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China. [10]Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center, Shenzhen University, Shenzhen, China. [11]Department of Allergy, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China. [12]Allergy Center, West China Hospital, Sichuan University, Chengdu, China. [13]The Second Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China. [14]Department of Respiratory and Critical Care Medicine, Shanghai Ruijin Hospital affiliated to Shanghai Jiaotong University school of medicine, Shanghai, China. [15]Department of Allergy and Clinical Immunology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. [16]Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. [17]Department of Respirology, Children's Hospital, Soochow University, Suzhou, China. [18]Department of Allergy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Key Laboratory of Major Diseases in Children, Ministry of Education, China National Clinical Research Center for Respiratory Diseases, Beijing, China. [19]School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China. [20]Department of Allergology, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China. [21]First Affiliated Hospital of Kunming Medical University, Kunming, China.

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关键词： allergen China component resolved diagnosis consensus IgE

摘要：

Allergen component resolved diagnosis (CRD) is a method for identifying specific protein molecules that cause hypersensitivity. Unlike traditional methods that use crude allergen extracts containing multiple component species, CRD focuses on individual allergen protein molecules for more precise diagnosis. The World Allergy Organization (WAO) recommends CRD as a supplement to clinical history and allergen extract testing, and in some cases, it can replace crude extract tests.CRD involves the use of natural or recombinant proteins to detect specific IgE antibodies directed at individual allergenic components. This method allows for a more detailed analysis of a patient's allergic response compared to the use of whole allergen extracts. The Allergy Prevention and Control Specialty Committee of the Chinese Preventive Medicine Association, in collaboration with multidisciplinary experts, developed an expert consensus that incorporates the consensus of the European Academy of Allergy and Clinical Immunology (EAACI), WAO, and important domestic literature on CRD in recent years.The consensus aims to standardize the algorithm of allergen diagnosis and provides a reference for clinical practice. It also offers guidance for clinicians on the common protein families identified by CRD, the scenarios where CRD is applicable, and the significance of detecting common allergen components.Despite its potential, CRD is not widely used in clinical practice in China due to the lack of allergen component reagents and a general unawareness among clinicians about CRD's application and interpretation of test results. The expert consensus developed by the Chinese Preventive Medicine Association aims to address this gap and enhance the clinical application of CRD in China.© 2024 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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大类 | 2 区医学

小类 | 2 区儿科 3 区过敏 3 区免疫学

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Q1 PEDIATRICS Q2 ALLERGY Q2 IMMUNOLOGY

影响因子： 4.3 最新[2023版] 4.5 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 4.3 出版前一年[2023版]

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第一作者机构： [1]Department of Clinical Laboratory, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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Chinese expert consensus on allergen component resolved diagnosis

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