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Impairment of white matter microstructure and structural network in patients with systemic lupus erythematosus

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资源类型：
Pubmed体系：
作者：
Bai Ru[1] * ; Yang Yifan[1] * ; Liu Shuang[1] * ; Li Shu[1] ; Zhao Ruotong[1] ; Wang Xiangyu[1] ; Cheng Yuqi[2,3,*2] ; Xu Jian[1,*1] ;
机构： [1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China [2]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China [3]Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
出处：
DOI： 10.1016/j.semarthrit.2024.152620
ISSN：

关键词： Systemic lupus erythematosus Diffusion tensor imaging Fractional anisotropy White matter structure network

摘要：
The study aimed to investigate the damage of white matter (WM) microstructure and structural network in patients with systemic lupus erythematosus (SLE) using diffusion tensor imaging.Tract-based spatial statistics (TBSS) were used to compare the difference in WM fractional anisotropy (FA) between SLE and HCs groups. The differences in WM networks between groups are compared using graph theory. The correlation between clinical data and SLE abnormal WM structure and network was analysed.The sample included 140 SLE patients and 111 healthy controls (HCs). Due to data missing, excessive head movement amplitude, failure of quality control and other reasons, 127 cases of SLE (103 females, mean age 29.84 years (SD 7.00), median years of education 12.00, interquartile range(9.00,15.00) and a median course of disease (month) 12.00, interquartile range (3.00,24.00)) and 102 cases of HCs (76 females, mean age 30.63 years (SD 7.24), median years of education 15.00, interquartile range(12.00,16.00)) were finally included in the study. The FA values of 5 clusters involving the right retrolenticular part of the internal capsule (RLIC), the genu of corpus callosum (GCC), the body of corpus callosum, the splenium of corpus callosum (SCC), were significantly lower in the SLE group compared to the HCs (P < 0.05 with threshold-free cluster enhancement corrected). The SLEDAI showed a negative correlation with FA in GCC, and HAMD showed a negative correlation with FA in SCC and right RLIC (P < 0.05). Regarding network indicators, Cp, Eglob, and Eloc were significantly decreased, while Lp was significantly increased in the SLE group. The degree centrality (DC) of 6 brain regions and the Enodal of 17 regions were significantly lower in the SLE group. SLEDAI showed a negative correlation with the area under the curve (AUC) of DC and Enodal in the left inferior frontal gyrus triangular (q < 0.05 with false discovery rate corrected), while MMSE showed a positive correlation with the Enodal in the left hippocampus (P < 0.05).The study concludes that changes in WM microstructure and its structural network may contribute to the development of severe neuropsychiatric symptoms in SLE patients. These changes may be the basis of brain damage that leads to the development of NPSLE from SLE without major neuropsychiatric manifestations.Copyright © 2024. Published by Elsevier Inc.

基金：
This work was supported by grants from the National Natural ScienceFoundation of China (32270947, 81760296, 82060259), Yunnan Province High-level health technical talents (leading talents) (L-2019004 andL-2019011), Yunnan Province Special Project for Famous Medical Talents of the “Ten Thousand Talents Program” (YNWRMY-2018-040 andYNWR-MY-2018-041), the Funding of Yunnan Provincial Health Scienceand Technology Plan (2017NS051 and 2018NS0133), the Funding ofMinistry of Science and Technology of Yunnan Province (2018ZF016),Yunnan Province Clinical Research Center for Skin Immune Diseases(2019ZF012), and Yunnan Province Clinical Center for Skin ImmuneDiseases (ZX2019-03-02), and Doctoral Research Fund Project of theFirst Affiliated Hospital of Kunming Medical University (newlyappointed doctoral research specialty) (2023BS018), Yunnan AppliedBasic Research Projects, Kunming Medical University Union SpecialFund (202301AY070001-159), 535 Talent Project of First AffiliatedHospital of Kunming Medical University (2022535Q01), and The YouthTalent of Ten Thousand Scientists Program of Yunnan Province (YNWRQNBJ-2018-152)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 风湿病学
第一作者：
第一作者机构： [1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China [2]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China [3]Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China [*1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road,Kunming, 650032, China. [*2]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming, 650032, China.Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, 305 Tianmushan Road, Hangzhou, 310058, China.
推荐引用方式(GB/T 7714)：
Bai Ru,Yang Yifan,Liu Shuang,et al.Impairment of white matter microstructure and structural network in patients with systemic lupus erythematosus[J].Seminars In Arthritis And Rheumatism.2024,71:152620.doi:10.1016/j.semarthrit.2024.152620.
APA：
Bai Ru,Yang Yifan,Liu Shuang,Li Shu,Zhao Ruotong...&Xu Jian.(2024).Impairment of white matter microstructure and structural network in patients with systemic lupus erythematosus.Seminars In Arthritis And Rheumatism,71,
MLA：
Bai Ru,et al."Impairment of white matter microstructure and structural network in patients with systemic lupus erythematosus".Seminars In Arthritis And Rheumatism 71.(2024):152620

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