Vitamin D is a fat-soluble vitamin implicated in the etiology, progression, and prognosis of breast cancer, yet its precise mechanisms of action remain elusive. We have integrated the latest insights from both basic and clinical research to find that in the human body, vitamin D is activated by hydroxylase to form the active form 1,25 (OH)2D. 1,25(OH)2D may stimulate the abundance of butyrate-producing bacteria by upregulating their abundance, and butyrate can regulate the intestinal microenvironment and modulate the immune system to inhibit the proliferation of breast cancer. Notably, our investigations reveal a novel role of vitamin D in modulating the gut microbiome, particularly in stimulating the production of butyrate and other metabolites, which exhibit potent anti-proliferative effects on breast cancer cells. These findings open promising avenues for innovative clinical approaches in breast cancer therapy. This review delves into the intricate interplay between vitamin D, butyrate, and breast cancer, aiming to propose novel therapeutic strategies.
基金：
National Natural Science Foundation of China [82060538, 82060543]; Middle-aged and Young Academic and Technical Leader Reserve Talent Program of Yunnan Province Science and Technology Department [202205AC160008]; Key Project of Yunnan Applied Basic Research [202401AS070023]; The 535 Talent Project of the First Affiliated Hospital of Kunming Medical University [2023535D10]; Yunnan Provincial Education Department [2024J0248]; Yunnan Provincial Science and Tech-nology Department Science and Technology Project [202301AY070001-009]
第一作者机构：[1]Kunming Med Univ, Yunnan Key Lab Breast Canc Precis Med, Peking Univ,Canc Hosp Yunnan, Yunnan Canc Hosp,Affiliated Hosp 3,Dept Breast Sur, Kunming 650118, Yunnan, Peoples R China
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推荐引用方式(GB/T 7714)：
Gong Fuhong,Liu Nianqiu,Miao Jingge,et al.Vitamin D regulation of gut microbiota-derived butyrate as a potential inhibitor of breast cancer proliferation[J].GENE.2026,976:doi:10.1016/j.gene.2025.149872.
APA：
Gong, Fuhong,Liu, Nianqiu,Miao, Jingge,Wang, Chenxi,Lin, Mengping...&Chen, Wenlin.(2026).Vitamin D regulation of gut microbiota-derived butyrate as a potential inhibitor of breast cancer proliferation.GENE,976,
MLA：
Gong, Fuhong,et al."Vitamin D regulation of gut microbiota-derived butyrate as a potential inhibitor of breast cancer proliferation".GENE 976.(2026)
