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JNK3 involvement in nerve cell apoptosis and neurofunctional recovery after traumatic brain injury☆

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收录情况： ◇ SCIE ◇ CSCD-C

作者：

机构： [1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China [2]Neuroscience Institute of Kunming Medical University, Kunming 650500, Yunnan Province, China

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关键词： neural regeneration JNK1 JNK2 JNK3 traumatic brain injury TdT-mediated dUTP nick end labeling reverse transcription-PCR cell apoptosis neurological function recovery neuroregeneration

摘要：

Increasing evidence has revealed that the activation of the JNK pathway participates in apoptosis of nerve cells and neurological function recovery after traumatic brain injury. However, which genes in the JNK family are activated and their role in traumatic brain injury remain unclear. Therefore, in this study, in situ end labeling, reverse transcription-PCR and neurological function assessment were adopted to investigate the alteration of JNK1, JNK2 and JNK3 gene expression in cerebral injured rats, and their role in cell apoptosis and neurological function restoration. Results showed that JNK3 expression significantly decreased at 1 and 6 hours and 1 and 7 days post injury, but that JNK1 and JNK2 expression remained unchanged. In addition, the number of apoptotic nerve cells surrounding the injured cerebral cortex gradually reduced over time post injury. The Neurological Severity Scores gradually decreased over 1, 3, 5, 14 and 28 days post injury. These findings suggested that JNK3 expression was downregulated at early stages of brain injury, which may be associated with apoptosis of nerve cells. Downregulation of JNK3 expression may promote the recovery of neurological function following traumatic brain injury.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区细胞生物学 4 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区神经科学

JCR分区：

出版当年[2013]版：

Q4 CELL BIOLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES Q2 CELL BIOLOGY

影响因子： 5.9 最新[2023版] 5.2 最新五年平均 0.234 出版当年[2013版] 0.169 出版当年五年平均 0.144 出版前一年[2012版] 0.22 出版后一年[2014版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China [*1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China

共同第一作者：

通讯作者：

通讯机构： [*1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China [*2]Neuroscience Institute of Kunming Medical University, Kunming 650500, Yunnan Province, China

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