Objective: To explore the correlation between the E211 G > A androgen receptor( AR) gene polymorphism and female postadolescent acne of Han Chinese, and lay the foundation for genetic studies of female postadolescent acne of Han Chinese. Methods: The female postadolescent acne patients (n = 79) and the healthy people (n = 80) were individed into female postadolescent acne group and control group. The polymorphism was investigated by PCR using DNA from peripheral blood lymphocytes. The transition (G > A) in the risk allele (A) produced a new recognition site for the restriction endonuclease Stu I. Three genotypes of AR-E211 G > A gene (GG, GA, AA) were determined, and the differences in the frequencies of the genotype and the allele between female postadolescent acne group and control group were observed. Results There was a significant difference in the frequency of the genotype GA + AA in the AR-E211 genetic polymorphisms between female postadolescent acne patients and healthy control (P = 0.028, OR = 0.937, OR 95% CI = 0.885 - 0.992); and there was also a significant difference in the allele (A) frequency between female postadolescent acne patients and healthy control (P = -0.029, OR = 0.968, OR 95% CI = 0.941-0.996). Conclusion: The high frequency of A allele in the functional G1733A polymorphism of AR-E211 is a decreased risk factor for female postadolescent acnein Han Chinese.