The improvement of infantile atopic dermatitis during the maintenance period: A multicenter, randomized, parallel controlled clinical study of emollients in Prinsepia utilis Royle
In order to investigate the effect of daily emollient treatment on infantile atopic dermatitis (AD) during the maintenance period, a total of 309 children younger than 2 years with moderate AD (155 and 154 in the treatment and control groups, respectively) were enrolled in this multicenter, randomized, parallel controlled clinical trial. Subjects were topically treated with desonide cream and emollients in Prinsepia utilis Royle for 2-4 weeks before entering the maintenance period and then differentially treated with either emollients for treatment or none for control. The cumulative maintenance rate, time to flare and improvement of eczema area and severity index (EASI) and infant's dermatitis quality of life index (IDQOL) were evaluated. Results showed that the cumulative maintenance rate of the treatment group (60.5%, 95% CI 50.0-69.4%) was significantly higher than that of the control group (23.5%, 95% CI 15.2-33.0%) (p < .001). The median time to flare in the treatment group was 90 days (interquartile range, IQR 28-90), which was significantly longer than that in the control group (28 days [IQR 18-67]) (p < .001). At Week 4 in the maintenance period, the EASI and IDQOL scores of the treatment group were lower than those of the control group. In conclusion, the application of emollients during the maintenance period of infantile AD can significantly reduce the risk of AD flares, prolong the time to flare and improve the clinical symptoms.
基金：
Beijing Talents Fund [2017000021469G248]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81673042]; Pediatric Medical Coordinated Development Center of Beijing Municipal Administration [XTZD20180502]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Dermatol, Beijing, Peoples R China
通讯作者：
通讯机构：[5]Kunming Med Univ, Dept Dermatol, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China[7]Capital Med Univ, Beijing Childrens Hosp, Dept Dermatol, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Shan,Wang Liuhui,Li Ping,et al.The improvement of infantile atopic dermatitis during the maintenance period: A multicenter, randomized, parallel controlled clinical study of emollients in Prinsepia utilis Royle[J].DERMATOLOGIC THERAPY.2020,33(2):doi:10.1111/dth.13153.
APA：
Wang, Shan,Wang, Liuhui,Li, Ping,Shu, Hong,Shen, Chunping...&Ma, Lin.(2020).The improvement of infantile atopic dermatitis during the maintenance period: A multicenter, randomized, parallel controlled clinical study of emollients in Prinsepia utilis Royle.DERMATOLOGIC THERAPY,33,(2)
MLA：
Wang, Shan,et al."The improvement of infantile atopic dermatitis during the maintenance period: A multicenter, randomized, parallel controlled clinical study of emollients in Prinsepia utilis Royle".DERMATOLOGIC THERAPY 33..2(2020)
