Background Chemotherapy is the standard treatment for non-small cell lung cancer (NSCLC). However, chemoresistance frequently occurs, making the treatment of NSCLC more difficult. Method We combined clinical and experimental studies to establish the role of microRNA (miR)-34c in NSCLC metastasis and chemoresistance. Results MiR-34c expression was significantly decreased in patients with NSCLC who showed a poor chemoresponse and metastasis. Overexpression of miR-34c sensitized NSCLC cells to paclitaxel and cisplatin both in vitro and in vivo. Furthermore, we found that NOTCH1 was target of miR-34c in NSCLC cells and played a key role in the effects of miR-34c on NSCLC. Conclusion NSCLC metastasis and chemoresistance are suppressed though the miR-34c/NOTCH1 axis. MiR-34c has important implications in the development of therapeutic strategies for metastasis and chemoresistance in NSCLC.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81060010]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2020]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Kunming, Yunnan, Peoples R China
通讯作者：
通讯机构：[2]Kunming Med Univ, Affiliated Hosp 1, Dept Anesthesiol, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Lin-zhu,Lei Chang-cheng,Zhao Yun-ping,et al.MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2020,48(3):doi:10.1177/0300060520904847.
APA：
Yang, Lin-zhu,Lei, Chang-cheng,Zhao, Yun-ping,Sun, Hong-wen,Yu, Qing-he...&Zhan, Xi.(2020).MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48,(3)
MLA：
Yang, Lin-zhu,et al."MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48..3(2020)
