详情页 - 昆明医科大学第一附属医院知识库

当前位置：首页 > 详情页

Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naive major depressive disorder patients

107| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE ◇ SSCI

作者：

机构： [1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang RD, Kunming 650032, Kunming, Yunnan, China [2]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical Unversity, Kunming, Yunnan, China [3]Imaging Center, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

出处：

DOI：

ISSN：

关键词： TPH2 Major depressive disorder TBSS White matter

摘要：

Considerable evidence suggests that the tryptophan hydroxylase-2 (TPH2) gene is associated with the pathophysiology of major depressive disorder (MDD). In the present study, we investigated alterations of white matter (WM) integrity and the impact of TPH2 polymorphism on WM in a sample of 118 first-episode, medication-naive, MDD patients and 118 well-matched healthy controls. Whole brain analyses of fractional anisotropy (FA) were performed using tract-based spatial statistics (TBSS). The results showed that the MDD group had significantly reduced FA values for the genu and body of the corpus callosum (CC) and the bilateral anterior corona radiate (ACR). In the MDD patient group, the GG homozygote subgroup exhibited a widespread reduction of FA (uncorrected) and significantly reduced FA in the left retrolenticular portion of the internal capsule and left superior longitudinal fasciculus (SLF) compared with those of the T carriers (GT/TT) (FWE corrected). No significant correlation was found between the FA values in any brain region and the patients' clinical variables. Our findings demonstrate the presence of abnormal white matter integrity in untreated patients with first-episode depression. TPH2-rs4570625 polymorphisms may be involved in the pathological mechanism of WM micro-architecture in patients.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经成像 4 区精神病学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经成像 4 区精神病学

JCR分区：

出版当年[2019]版：

Q3 CLINICAL NEUROLOGY Q3 PSYCHIATRY Q4 NEUROIMAGING

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q3 PSYCHIATRY Q3 NEUROIMAGING

影响因子： 2.1 最新[2023版] 2.3 最新五年平均 2.063 出版当年[2019版] 2.514 出版当年五年平均 2.27 出版前一年[2018版] 2.376 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang RD, Kunming 650032, Kunming, Yunnan, China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder [2]White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder. [3]White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder. [4]Alternations of White Matter Structural Networks in First Episode Untreated Major Depressive Disorder with Short Duration [5]Elevated serum neurofilament levels in young first-episode and medication-naïve major depressive disorder patients with alterative white matter integrity. [6]Disrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts [7]Elevated serum neurofilament levels in young first-episode and medication-naïve major depressive disorder patients with alterative white matter integrity [8]Age-related heterogeneity revealed by disruption of white matter structural networks in patients with first-episode untreated major depressive disorder: WM Network In OA-MDD. [9]Association between abnormal serum myelin-specific protein levels and white matter integrity in first-episode and drug-naive patients with major depressive disorder [10]Shared and Distinct White Matter Alterations in Major Depression and Bipolar Disorder: A Systematic Review and Meta-Analysis