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White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ SSCI

作者：
He Mengxin[1,2] * ; Cheng Yuqi[1,2] ; Chu Zhaosong[1,2] ; Wang Xin[1] ; Xu Jinlei[1] ; Lu Yi[3] ; Shen Zonglin[1,2,4] ; Xu Xiufeng[2] ;
机构： [1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China, [2]Yunnan Clinical Research Center for Mental Disorders, Kunming, China, [3]Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, China, [4]Mental Health Institute of Yunnan, First Affiliated Hospital of Kunming Medical University, Kunming, China
出处：
DOI： 10.3389/fpsyt.2022.816191
ISSN：

关键词： melancholic depression non-melancholic depression diffusion tensor imaging WM network small-world

摘要：
The efficacy and prognosis of major depressive disorder (MDD) are limited by its heterogeneity. MDD with melancholic features is an important subtype of MDD. The present study aimed to reveal the white matter (WM) network changes in melancholic depression.Twenty-three first-onset, untreated melancholic MDD, 59 non-melancholic MDD patients and 63 health controls underwent diffusion tensor imaging (DTI) scans. WM network analysis based on graph theory and support vector machine (SVM) were used for image data analysis.Compared with HC, small-worldness was reduced and abnormal node attributes were in the right orbital inferior frontal gyrus, left orbital superior frontal gyrus, right caudate nucleus, right orbital superior frontal gyrus, right orbital middle frontal gyrus, left rectus gyrus, and left median cingulate and paracingulate gyrus of MDD patients. Compared with non-melancholic MDD, small-worldness was reduced and abnormal node attributes were in right orbital inferior frontal gyrus, left orbital superior frontal gyrus and right caudate nucleus of melancholic MDD. For correlation analysis, the 7th item score of the HRSD-17 (work and interest) was positively associated with increased node betweenness centrality (aBC) values in right orbital inferior frontal gyrus, while negatively associated with the decreased aBC in left orbital superior frontal gyrus. SVM analysis results showed that abnormal aBC in right orbital inferior frontal gyrus and left orbital superior frontal gyrus showed the highest accuracy of 81.0% (69/83), the sensitivity of 66.3%, and specificity of 85.2% for discriminating MDD patients with or without melancholic features.There is a significant difference in WM network changes between MDD patients with and without melancholic features.Copyright © 2022 He, Cheng, Chu, Wang, Xu, Lu, Shen and Xu.

基金：
Yunnan Basic Research Projects- Union Foundation [2019FE001(-144)], Yunnan Clinical Research Center for Mental Disorders (202102AA100058), National Natural Science Foundation of China (81660237), Yunnan Health Training Project of High Level Talents (H- 2018090), and Yunnan Provincial Health Institute Research Project (2018NS0109).

基金编号： 2019FE001(-144)

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 精神病学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 精神病学
JCR分区：
出版当年[2022]版：
Q2 PSYCHIATRY
最新[2023]版：
Q2 PSYCHIATRY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China, [2]Yunnan Clinical Research Center for Mental Disorders, Kunming, China,
通讯作者：
通讯机构： [1]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China, [2]Yunnan Clinical Research Center for Mental Disorders, Kunming, China, [4]Mental Health Institute of Yunnan, First Affiliated Hospital of Kunming Medical University, Kunming, China
推荐引用方式(GB/T 7714)：
He Mengxin,Cheng Yuqi,Chu Zhaosong,et al.White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder.[J].FRONTIERS IN PSYCHIATRY.2022,13:816191.doi:10.3389/fpsyt.2022.816191.
APA：
He Mengxin,Cheng Yuqi,Chu Zhaosong,Wang Xin,Xu Jinlei...&Xu Xiufeng.(2022).White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder..FRONTIERS IN PSYCHIATRY,13,
MLA：
He Mengxin,et al."White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder.".FRONTIERS IN PSYCHIATRY 13.(2022):816191

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