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LINC00857 knockdown inhibits cell proliferation and induces apoptosis via involving STAT3 and MET oncogenic proteins in esophageal adenocarcinoma

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收录情况： ◇ SCIE

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机构： [1]Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China [2]Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Center for Translational Medicine & School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China [3]Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510000, China [4]Department of Organ Transplant, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [5]Section of Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA [6]School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China

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关键词： LINC00857 esophageal adenocarcinoma proliferation apoptosis

摘要：

Esophageal adenocarcinoma (EAC) is one of the leading causes of cancer-related death worldwide, and the molecular biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs are dysregulated in a variety of cancers including EAC. In this study, siRNA mediated gene knockdown, Western blot, RT-PCR, as well as oncogenic function assay were performed. We found that the cell proliferation, colony formation, invasion and migration were decreased after LINC00857 knockdown in EAC cell lines. We also found that knockdown LINC00857 could induce apoptosis. Mechanistically, we found that the MET, STAT3, c-Myc and p-CREB proteins were decreased after LINC00857 knockdown. Our study suggests that LINC00857 may play an important oncogenic role in EAC via STAT3 and MET signaling.

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出版当年[2020]版：

大类 | 2 区

医学

小类 | 1 区老年医学 3 区细胞生物学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区老年医学

JCR分区：

出版当年[2019]版：

Q1 GERIATRICS & GERONTOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 4.831 出版当年[2019版] 5.397 出版当年五年平均 5.515 出版前一年[2018版] 5.682 出版后一年[2020版]

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第一作者机构： [1]Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China

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LINC00857 knockdown inhibits cell proliferation and induces apoptosis via involving STAT3 and MET oncogenic proteins in esophageal adenocarcinoma

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