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LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling

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收录情况： ◇ SCIE

作者：
Su, Wenmei[1] * ; Guo, Chunfang[2] ; Wang, Lihui[3,4] ; Wang, Zhuwen[2] ; Yang, Xia[5] ; Niu, Feiyu[6] ; Tzou, Daniel[2] ; Yang, Xiao[1] ; Huang, Xiaobi[1] ; Wu, Jiancong[1] ; Chen, Xiaorao[1] ; Zou, Lei[7] ; Yang, Zhixiong[1] ; Chen, Guoan[8] ;
机构： [1]Guangdong Med Univ, Dept Pulm Oncol, Affiliated Hosp, Zhanjiang, Peoples R China [2]Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA [3]Guangxi Med Univ, Ctr Translat Med, Key Lab Longev & Aging Related Dis Chinese,Minis, Nanning, Guangxi, Peoples R China [4]Guangxi Med Univ, Sch Preclin Med, Nanning, Guangxi, Peoples R China [5]Xi An Jiao Tong Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China [6]Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou, Guangdong, Peoples R China [7]Kunming Med Univ, Dept Organ Transplant, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China [8]Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
出处：
DOI： 10.18632/aging.102071
ISSN：

关键词： esophageal adenocarcinoma MIR22HG proliferation migration invasion

摘要：
Long non-coding RNAs (IncRNAs) have involved in human malignancies and played an important role in gene regulations. The dysregulation of IncRNA MIR22HG has been reported in several cancers. However, the role of MIR22HG in esophageal adenocarcinoma (EAC) is poorly understood. Loss of function approaches were used to investigate the biological role of MIR22HG in EAC cells. The effects of MIR22HG on cell proliferation were evaluated by WST-1 and colony formation assays. The effects of MIR22HG on cell migration and invasion were examined using transwell assays. QRT-PCR and Western blot were used to evaluate the mRNA and protein expression of related genes. In this study, abrogation of MIR22HG inhibited cell proliferation, colony formation, invasion and migration in EAC 3 cell lines (OE33, OE19 and FLO-1). Mechanistically, MIR22HG silencing decreased the expression of STAT3/c-Myc/p-FAK proteins and induced apoptosis in EAC cell lines. These results delineate a novel mechanism of MIR22HG in EAC, and may provide potential targets by developing IncRNA-based therapies for EAC.

基金：
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China [81702270, 81871883, 81803564]; Affiliated Hospital of Guangdong Medical University Doctoral Foundation [2018052638]; Guangxi Natural Science FoundationNational Natural Science Foundation of Guangxi Province [2015GXNSFBA139117]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M633619XB]; General Project of Key Research and Development Program of Shaanxi Province [2018SF-074]
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外文
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 1 区 老年医学 3 区 细胞生物学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 细胞生物学 3 区 老年医学
JCR分区：
出版当年[2019]版：
Q1 GERIATRICS & GERONTOLOGY Q2 CELL BIOLOGY
最新[2023]版：
Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Guangdong Med Univ, Dept Pulm Oncol, Affiliated Hosp, Zhanjiang, Peoples R China
通讯作者：
通讯机构： [1]Guangdong Med Univ, Dept Pulm Oncol, Affiliated Hosp, Zhanjiang, Peoples R China [8]Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
推荐引用方式(GB/T 7714)：
Su Wenmei,Guo Chunfang,Wang Lihui,et al.LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling[J].AGING-US.2019,11(13):4587-4596.doi:10.18632/aging.102071.
APA：
Su, Wenmei,Guo, Chunfang,Wang, Lihui,Wang, Zhuwen,Yang, Xia...&Chen, Guoan.(2019).LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling.AGING-US,11,(13)
MLA：
Su, Wenmei,et al."LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling".AGING-US 11..13(2019):4587-4596

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