个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Su, Wenmei[1] ; Guo, Chunfang[2] ; Wang, Lihui[3,4] ; Wang, Zhuwen[2] ; Yang, Xia[5] ; Niu, Feiyu[6] ; Tzou, Daniel[2] ; Yang, Xiao[1] ; Huang, Xiaobi[1] ; Wu, Jiancong[1] ; Chen, Xiaorao[1] ; Zou, Lei[7] ; Yang, Zhixiong[1] ; Chen, Guoan[8] ;
机构： [1]Guangdong Med Univ, Dept Pulm Oncol, Affiliated Hosp, Zhanjiang, Peoples R China [2]Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA [3]Guangxi Med Univ, Ctr Translat Med, Key Lab Longev & Aging Related Dis Chinese,Minis, Nanning, Guangxi, Peoples R China [4]Guangxi Med Univ, Sch Preclin Med, Nanning, Guangxi, Peoples R China [5]Xi An Jiao Tong Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China [6]Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou, Guangdong, Peoples R China [7]Kunming Med Univ, Dept Organ Transplant, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China [8]Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
出处：
DOI： 10.18632/aging.102071
ISSN：

关键词： esophageal adenocarcinoma MIR22HG proliferation migration invasion

摘要：
Long non-coding RNAs (IncRNAs) have involved in human malignancies and played an important role in gene regulations. The dysregulation of IncRNA MIR22HG has been reported in several cancers. However, the role of MIR22HG in esophageal adenocarcinoma (EAC) is poorly understood. Loss of function approaches were used to investigate the biological role of MIR22HG in EAC cells. The effects of MIR22HG on cell proliferation were evaluated by WST-1 and colony formation assays. The effects of MIR22HG on cell migration and invasion were examined using transwell assays. QRT-PCR and Western blot were used to evaluate the mRNA and protein expression of related genes. In this study, abrogation of MIR22HG inhibited cell proliferation, colony formation, invasion and migration in EAC 3 cell lines (OE33, OE19 and FLO-1). Mechanistically, MIR22HG silencing decreased the expression of STAT3/c-Myc/p-FAK proteins and induced apoptosis in EAC cell lines. These results delineate a novel mechanism of MIR22HG in EAC, and may provide potential targets by developing IncRNA-based therapies for EAC.

基金：
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China [81702270, 81871883, 81803564]; Affiliated Hospital of Guangdong Medical University Doctoral Foundation [2018052638]; Guangxi Natural Science FoundationNational Natural Science Foundation of Guangxi Province [2015GXNSFBA139117]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M633619XB]; General Project of Key Research and Development Program of Shaanxi Province [2018SF-074]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 1 区 老年医学 3 区 细胞生物学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 细胞生物学 3 区 老年医学
JCR分区：
出版当年[2019]版：
Q1 GERIATRICS & GERONTOLOGY Q2 CELL BIOLOGY
最新[2023]版：
Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Guangdong Med Univ, Dept Pulm Oncol, Affiliated Hosp, Zhanjiang, Peoples R China
通讯作者：
通讯机构： [1]Guangdong Med Univ, Dept Pulm Oncol, Affiliated Hosp, Zhanjiang, Peoples R China [8]Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
推荐引用方式(GB/T 7714)：
Su Wenmei,Guo Chunfang,Wang Lihui,et al.LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling[J].AGING-US.2019,11(13):4587-4596.doi:10.18632/aging.102071.
APA：
Su, Wenmei,Guo, Chunfang,Wang, Lihui,Wang, Zhuwen,Yang, Xia...&Chen, Guoan.(2019).LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling.AGING-US,11,(13)
MLA：
Su, Wenmei,et al."LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling".AGING-US 11..13(2019):4587-4596

相关文献

[1]Nucleophosmin promotes lung adenocarcinoma cell proliferation, migration and invasion by activating the EGFR/MAPK signaling pathway [2]OTX1 is a novel regulator of proliferation, migration, invasion and apoptosis in lung adenocarcinoma [3]MicroRNA-335 suppresses the proliferation, migration, and invasion of breast cancer cells by targeting EphA4 [4]KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2 [5]CASC2 inhibits the growth, migration, and invasion of thyroid cancer cells through sponging miR-18a-5p/FIH1 axis [6]LINC00857 knockdown inhibits cell proliferation and induces apoptosis via involving STAT3 and MET oncogenic proteins in esophageal adenocarcinoma [7]MicroRNA-19a regulates the proliferation, migration and invasion of human gastric cancer cells by targeting CUL5 [8]MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma [9]Up-regulation of CKAP2L expression promotes lung adenocarcinoma invasion and is associated with poor prognosis [10]p300-Catalyzed Lysine Crotonylation Promotes the Proliferation, Invasion, and Migration of HeLa Cells via Heterogeneous Nuclear Ribonucleoprotein A1(Open Access)

资源点击量：52537 今日访问量：0 总访问量：1562 更新日期：2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 昆明医科大学第一附属医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西昌路295号(650032)