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CASC2 inhibits the growth, migration, and invasion of thyroid cancer cells through sponging miR-18a-5p/FIH1 axis

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收录情况： ◇ SCIE

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机构： [1]Department of General Surgery, Ganmei Affiliated Hospital of Kunming Medical University (First People's Hospital of Kunming), Kunming, China [2]Department of Thyroid Surgery, First Affiliated Hospital of Kunming MedicalUniversity, Kunming, China

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关键词： CASC2 invasion proliferation thyroid cancer

摘要：

Long noncoding RNA (lncRNA) Cancer Susceptibility 2 (CASC2) has been proved to contribute to the development of cancers. However, the mechanism behind the action of CASC2 in thyroid cancer is not quite clear. We demonstrated that CASC2 was downregulated in thyroid cancer. We noted that CASC2 overexpression restrained the growth, migration, and invasion of thyroid cancer cells, whereas CASC2 depletion caused opposite trends. Bioinformatics analysis predicted that hypoxia inducible factor 1 subunit alpha inhibitor (FIH-1) was potentially targeted by miR-18a-5p, which was confirmed by luciferase reporter assay. Upregulation of FIH-1 abrogated the promotive effect of miR-18a-5p on the growth and invasion of thyroid cancer cells. In addition, CASC2 serves as a competing endogenous RNA (ceRNA) and a ''sponge'' for miR-18a-5p, thereby regulating the expression of FIH-1. These data elucidated the CASC2/miR-18a-5p ceRNA network in thyroid cancer pathogenesis.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

JCR分区：

出版当年[2021]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.7 最新[2023版] 3 最新五年平均 2.996 出版当年[2021版] 2.947 出版当年五年平均 2.744 出版前一年[2020版] 3.3 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of General Surgery, Ganmei Affiliated Hospital of Kunming Medical University (First People's Hospital of Kunming), Kunming, China

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通讯作者：

通讯机构： [2]Department of Thyroid Surgery, First Affiliated Hospital of Kunming MedicalUniversity, Kunming, China [*1]Department of ThyroidSurgery, First Affiliated Hospital of KunmingMedical University, No.295 Xichang Road,Kunming, Yunnan, China

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