机构:[a]Department of Head and Neck Surgery Section II, the Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kunming, China[b]Department of Oncology, Chuxiong people's Hospital, 318 Lucheng South Road, Chuxiong, China[c]Department of Medical Oncology, the First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, China内科科室肿瘤内科昆明医科大学附属第一医院[d]State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China
Platelet counts have been reported to be closely related to distant metastasis of many malignant tumors. Our previous study showed that elevated peripheral blood platelet counts may be an adverse prognostic factor of anaplastic thyroid carcinoma (ATC) patients, indicating that platelets may promote ATC progression. In the present study, we aimed to identify the role of platelets in ATC cell invasion and migration and to explore the underlying mechanisms. We found that platelets can promote the invasive and migratory of ATC cells, which may be related to the interaction between activated platelet-secreted chemokine (C-C motif) ligand 3 (CCL3) and its receptor CCR5. The interaction was shown to induce the upregulation of matrix metalloproteinase (MMP)-1 via NF-kappa B pathway. These findings could provide a new idea for the research of targeted platelets to inhibit tumor metastasis.
基金:
This work was supported by grants from the National Natural
Science Foundation of China (81560470 and 81773127), the Special
Foundation of Young and Middle-Aged Academic Leaders Reserve
Talent in Yunnan Province (2015HB086), Special Funds for High-Level
Medical Leaders in Yunnan Province (L-2017025), and Yunnan
Province Basic Research Program (2018FE001-058/246).
第一作者机构:[a]Department of Head and Neck Surgery Section II, the Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kunming, China[b]Department of Oncology, Chuxiong people's Hospital, 318 Lucheng South Road, Chuxiong, China
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推荐引用方式(GB/T 7714):
Wei Wang,Hong-Ying Chu,Zhao-Ming Zhong,et al.Platelet-secreted CCL3 and its receptor CCR5 promote invasive and migratory abilities of anaplastic thyroid carcinoma cells via MMP-1[J].CELLULAR SIGNALLING.2019,63:doi:10.1016/j.cellsig.2019.109363.
APA:
Wei Wang,Hong-Ying Chu,Zhao-Ming Zhong,Xiao Qi,Rui Cheng...&Chuan-Zheng Sun.(2019).Platelet-secreted CCL3 and its receptor CCR5 promote invasive and migratory abilities of anaplastic thyroid carcinoma cells via MMP-1.CELLULAR SIGNALLING,63,
MLA:
Wei Wang,et al."Platelet-secreted CCL3 and its receptor CCR5 promote invasive and migratory abilities of anaplastic thyroid carcinoma cells via MMP-1".CELLULAR SIGNALLING 63.(2019)