Background Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations. Methods We investigated the incidence of CIMP, BRAF/KRAS mutation, and microsatellite instability (MSI) in a Chinese population with CRC (n = 401) and analysed associations between CIMP status and clinicopathological and molecular features. Results A total of 41 cases, 310 cases, and 40 cases were classified as CIMP-high, CIMP-low, and CIMP-negative, respectively. We detected a significantly low incidence of BRAF mutation in adenomas (2%) and CRC (0.7%), and a relatively low incidence of KRAS mutation (24.9%) compared with that in other populations. We also detected a relatively low incidence of CIMP-high (10.2%), which was significantly associated with younger age (<= 49 years of age), female sex, and proximal tumour location. Conclusions This study revealed unique characteristics of CIMP in a Chinese population with colorectal cancer. Developing specific CIMP markers based on unique populations or ethnic groups will further help to fully elucidate CIMP pathogenesis.
基金：
Yunnan Applied Basic Research Projects-Union Foundation of Kunming Medical University [2017FE467(-132)]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81960504, 3171101074]; Key Science and Technology Planning Project of Kunming Science and Technology Bureau; Reproductive and Genetic Technology Innovation Team of Kunming Medical University [CXTD201708]; Hundred-Talent Program of Kunming Medical University [60118260104]; First Affiliated Hospital of Kunming Medical University [2017BS003]; [YLXL20170002]
第一作者机构：[1]Kunming Med Univ, Dept Reprod & Genet, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China[5]Yunnan Engn Technol Ctr Digest Dis, Kunming 650032, Yunnan, Peoples R China[6]Kunming Engn Technol Ctr Digest Dis, Kunming 650032, Yunnan, Peoples R China
通讯作者：
通讯机构：[4]Kunming Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Yunnan Inst Digest Dis, Kunming 650032, Yunnan, Peoples R China[5]Yunnan Engn Technol Ctr Digest Dis, Kunming 650032, Yunnan, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Jiang,Tang Li,Yi Jinhua,et al.Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer[J].BMC GASTROENTEROLOGY.2019,19(1):doi:10.1186/s12876-019-1086-x.
APA：
Liu, Jiang,Tang, Li,Yi, Jinhua,Li, Guimei,Lu, Youwang...&Wang, Kunhua.(2019).Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer.BMC GASTROENTEROLOGY,19,(1)
MLA：
Liu, Jiang,et al."Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer".BMC GASTROENTEROLOGY 19..1(2019)
