资源类型：
期刊
收录情况：
◇ 统计源期刊
◇ 北大核心
文章类型：
综述
机构：
[a]Department of Medical Oncology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
内科科室
肿瘤内科
昆明医科大学附属第一医院
[b]Department of Oncology, First affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
内科科室
肿瘤内科
昆明医科大学附属第一医院
出处：
World Chinese Journal of Digestology.2013,21(28):
ISSN：
1009-3079
关键词：
Diagnosis and screening
Hereditary nonpolyposis colorectal cancer
Microsatellite instability
Mismatch repair gene
摘要：
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a class of autosomal dominant genetic disease. Main clinical characteristics of HNPCC include early onset age, more common in the right colon, and concomitant with simultaneous or metachronous extracolonic cancers, including endometrial cancer, stomach cancer, and ovarian cancer. However, the prognosis of HNPCC is better than sporadic colorectal cancer. Screening and intervention for HNPCC among high-risk pedigree population can effectively reduce the cancer incidence and mortality. In this article we will review the pathogenesis, epidemiology, diagnosis, screening, prevention and treatment of HNPCC. © 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
第一作者：
Chen, C.-W
第一作者机构：
[a]Department of Medical Oncology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
通讯作者：
Dong, J
推荐引用方式(GB/T 7714)：
Chen C.-W,Zhu Z,Dong J.Hereditary nonpolyposis colorectal cancer(Open Access)[J].World Chinese Journal of Digestology.2013,21(28):
