机构：[1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China,内科科室风湿免疫科昆明医科大学附属第一医院[2]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China,内科科室精神科昆明医科大学附属第一医院[3]Magnetic ResonanceImaging Center, The First Hospital of Kunming, Kunming, China,[4]Key Laboratory of Nuclear Analysis, Institute of HighEnergy Physics, Chinese Academy of Sciences, Beijing, China,[5]Key Laboratory of Animal Models and Human DiseaseMechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
The aim of the study was to find structural brain changes in systemic lupus erythematosus patients without major neuropsychiatric manifestations [non-neuropsychiatric systemic lupus erythematosus (non-NPSLE)] using quantitative magnetic resonance imaging (MRI) and possible associations with clinical characteristics. 89 non-NPSLE patients with normal conventional MRI and 84 healthy controls (HCs) were recruited. The whole brain gray matter volume (GMV) and white matter volume (WMV) were calculated for each individual. We found obvious GMV and WMV reduction in the systemic lupus erythematosus (SLE) group compared with HCs. Female patients showed significant reduction of GMV and WMV compared with male patients. Patients treated with immunosuppressive agents (ISA) showed less WMV reduction than those without. Cognitive impairment was the most common subclinical neuropsychiatric manifestation and had a prevalence of 46.1%. Association between WMV reduction with cognitive impairment was found. Thus, we concluded that structural brain atrophy could happen even before occurrence of obvious neuropsychiatric signs and symptoms and was associated with subclinical symptoms such as cognitive impairment. ISA treatment might have a protective effect on the brain atrophy. Early treatment might prevent the progressive damage to the brain. More studies are needed to fully understand the complicated underlying mechanisms of brain atrophy in SLE.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81160379, 81460256, 81560233, 81501406, 81760296]; Funding of Yunnan Provincial Health Science and Technology Plan [2014NS171, 2016N5026, 2017NS051]; Innovative Research Team of Kunming Medical University [CXTD201613]; Yunnan Provincial Fund for Preparatory Young Leaders in Academia and Technology [2015H13071]; Funding of Ministry of Science and Technology of Yunnan Province [2014HC018]; Funding of Yunnan Provincial Department of Education; Yunnan Applied Basic Research Projects-Union Foundation [2017FE467, 2017FL467 (-138)]
第一作者机构：[1]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Shuang,Cheng Yuqi,Zhao Yueyin,et al.Clinical Factors Associated with Brain Volume Reduction in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations[J].FRONTIERS IN PSYCHIATRY.2018,9:doi:10.3389/fpsyt.2018.00008.
APA：
Liu, Shuang,Cheng, Yuqi,Zhao, Yueyin,Yu, Hongjun,Lai, Aiyun...&Xu, Jian.(2018).Clinical Factors Associated with Brain Volume Reduction in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations.FRONTIERS IN PSYCHIATRY,9,
MLA：
Liu, Shuang,et al."Clinical Factors Associated with Brain Volume Reduction in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations".FRONTIERS IN PSYCHIATRY 9.(2018)
