Background/Aims: Chronic heavy alcohol consumption may result in alcoholic cardiomyopathy. This study was designed to screen differentially expressed microRNAs and circular RNAs in heart tissue of mice with alcoholic cardiomyopathy to reveal the underlying molecular mechanism. Methods: Having established a murine alcoholic cardiomyopathy model, we screened differentially expressed microRNAs and circular RNAs in three heart samples from the alcohol-treated and control groups by high-throughput microarray analysis. We analyzed the function and biological signaling pathways of differentially expressed non-coding RNAs closely related to alcoholic cardiomyopathy using bioinformatics software to identify some mRNAs and their biological signaling pathways closely related to alcoholic cardiomyopathy. Results: Nineteen microRNAs and 265 circular RNAs were differentially expressed in the alcohol-treated group compared with the control group. After analyzing gene function and signaling pathways by bioinformatics software, we found that the differentially expressed mRNAs were associated with carbohydrate metabolism. Conclusions: Chronic alcohol consumption can change the non-coding RNA profile of heart tissue, which is closely related to the pathological mechanisms of alcoholic cardiomyopathy. (C) 2018 The Author(s) Published by S. Karger AG, Basel
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81160035, 81460044]; Yunnan Provincial Science and Technology Department [2014HB031, 2017FE468 (-039)]; Yunnan Health Training Project of High Level Talents
第一作者机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Kunming, Yunnan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Kunming, Yunnan, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Yuqiao,Chen Hongmei,Ding Nina,et al.Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy[J].CELLULAR PHYSIOLOGY AND BIOCHEMISTRY.2018,46(6):2284-2296.doi:10.1159/000489596.
APA：
Yang, Yuqiao,Chen, Hongmei,Ding, Nina,Wang, Shuo,Duan, Zhantao...&Qian, Jinqiao.(2018).Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,46,(6)
MLA：
Yang, Yuqiao,et al."Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 46..6(2018):2284-2296
