机构:[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China[2]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China内科科室皮肤科昆明医科大学附属第一医院[3]Yunnan University of Traditional Chinese Medicine, Kunming 650500, China[4]University of Chinese Academy of Sciences, Beijing 100039, China[5]Kunming Botanee Bio-Technique Co. Ltd., Kunming 650106, China
Four previously undescribed oleanane-type triterpenoid glycosides (dianshanchaosides A-D) were isolated from the twigs and leaves of Camellia reticulata, together with seven known analogues. Their structures were established by comprehensive spectroscopic data and chemical methods The triterpenoid glycosides were evaluated their inhibitory effects on the LPS-induced NO production in RAW264.7 macrophages and cytotoxicities against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480). Glycosides 2-6, 9, and 10 displayed significant cytotoxicities against the five human cancer lines with IC50 values in the range of 0.54-9.49 mu M.
基金:
Scientific and Technological Projects of Yunnan Province [2014IB008]; Innovation Team of the Ministry of Education [IRT-17R49]; National Natural Science Funding of ChinaNational Natural Science Foundation of China [31570363, 81460533]; Natural Science Foundation of Yunnan ProvinceNatural Science Foundation of Yunnan Province [2015FA031]; Kunming Science and Technology Bureau [2015-2-H-01451]
第一作者机构:[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China[3]Yunnan University of Traditional Chinese Medicine, Kunming 650500, China
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通讯作者:
推荐引用方式(GB/T 7714):
Chen Qi-Run,Li Dan,Qin Xu-Jie,et al.Bioactive triterpenoid glycosides from the twigs and leaves of Camellia reticulata[J].PHYTOCHEMISTRY LETTERS.2018,25:6-11.doi:10.1016/j.phytol.2018.03.002.
APA:
Chen, Qi-Run,Li, Dan,Qin, Xu-Jie,Liu, Hui,Ni, Wei...&Liu, Hai-Yang.(2018).Bioactive triterpenoid glycosides from the twigs and leaves of Camellia reticulata.PHYTOCHEMISTRY LETTERS,25,
MLA:
Chen, Qi-Run,et al."Bioactive triterpenoid glycosides from the twigs and leaves of Camellia reticulata".PHYTOCHEMISTRY LETTERS 25.(2018):6-11