机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院[2]Chinese Medicine College of Yun Nan, Kunming, Chinac[3]Public Health School of Kunming Medical University, Kunming, China
Here, we investigated the diagnostic performance of manganese (Mn)-enhanced magnetic resonance imaging (MEMRI) in colorectal cancer (CRC). The ability of CRC cell lines SW620 and SW480 to uptake Mn was evaluated and compared with a normal colon cell using MEMRI. Subcutaneous xenografts in nude mice underwent MRI examination at tumor sizes of 5, 10, and 15 mm. Contrast enhancement was compared between gadolinium (Gd)-and Mn-enhanced MRI. SW620 and SW480 cell lines took up more Mn2- than normal cells, resulting in 4.5 and 2 times greater T1 value shortening than normal cell using in vitro MEMRI (P < .001). Most xenografts (17/23) enhanced markedly on MEMRI. A heterogeneous enhancement pattern invariably noted whether Mn or Gd agents were administered, but tumors imaged using MEMRI showed a greater degree of enhancement with a larger extent of enhanced area than those imaged using Gd-enhanced MRI. The numbers of markedly Mn-enhanced cases were more in the 5-mm-size tumor group than in 10-or 15-mm-size tumor groups. Overall, MEMRI could enhance CRCs and it showed potential in detecting early small lesions and markedly enhancing tumors that had minimal Gd enhancement.
基金：
Applied Basic Research Project-Union Foundation of Science and Technique Department of Yunnan Province; Kunming Medical University [2017FE467(-048)]
第一作者机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming, China
通讯作者：
通讯机构：[*1]The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, 650000 Kunming, Yunnan Province, China
推荐引用方式(GB/T 7714)：
Wen Liang,Shi Xinan,He Liping,et al.Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers[J].TOMOGRAPHY.2018,4(2):78-83.doi:10.18383/j.tom.2018.00008.
APA：
Wen, Liang,Shi, Xinan,He, Liping&Han, Dan.(2018).Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers.TOMOGRAPHY,4,(2)
MLA：
Wen, Liang,et al."Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers".TOMOGRAPHY 4..2(2018):78-83
