机构：[1]First Department of Respiratory Medicine, Yan’an Hospital Affiliated to Kunming Medical University, No. 245, East Renmin Road, Kunming 650051, Yunnan, China[2]First Department of Respiratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China.内科科室呼吸内科呼吸与危重症一科昆明医科大学附属第一医院[3]Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China[4]The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi 653100, Yunnan, China.
Background: To determine the association of lymphatic vessel density (LVD) with the prognosis of Asian non-small cell lung cancer (NSCLC) patients via a meta-analysis. Methods: Eligible studies were selected by searching PubMed and EMBASE from inception to July 25, 2017. The reference lists of the retrieved articles were also consulted. The information was independently screened by two authors. When heterogeneity was significant, a random-effects model was used to determine overall pooled risk estimates. Results: A total of 15 studies with 1075 patients were finally included in the meta-analysis. LVD was positively associated with the prognosis of NSCLC in the overall analysis (hazard ratio (HR) 1.14, 95% confidence interval (95% CI): 1.02-1.27, p = 0.000, I-2 = 73.2%). Subgroup analyses were performed on 5 VEGFR-3 groups (p = 0.709, I-2 = 0.0%), 3 LYVE-1 groups (p = 0.01, I-2 = 86.4%), 5 D2-40 groups (p = 0.019, I-2 = 66.2%), and 2 podoplanin groups (p = 0.094, I-2 = 64.5%). Sensitivity analysis indicated robust results. There was no publication bias. Conclusions: LVD is an indicator of poor prognosis in Asian NSCLC patients.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81560694, 81760015]; Young Academic and Technical Leaders of Yunnan Province [2017HB053]; Medical Science Leaders of Yunnan Province [201627]
第一作者机构：[1]First Department of Respiratory Medicine, Yan’an Hospital Affiliated to Kunming Medical University, No. 245, East Renmin Road, Kunming 650051, Yunnan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Shuanglan,Yang Jiao,Xu Shuangyan,et al.Lymphatic vessel density as a prognostic indicator in Asian NSCLC patients: a meta-analysis[J].BMC PULMONARY MEDICINE.2018,18:doi:10.1186/s12890-018-0702-9.
APA：
Xu, Shuanglan,Yang, Jiao,Xu, Shuangyan,Zhu, Yun,Zhang, Chunfang...&Xing, Xiqian.(2018).Lymphatic vessel density as a prognostic indicator in Asian NSCLC patients: a meta-analysis.BMC PULMONARY MEDICINE,18,
MLA：
Xu, Shuanglan,et al."Lymphatic vessel density as a prognostic indicator in Asian NSCLC patients: a meta-analysis".BMC PULMONARY MEDICINE 18.(2018)
