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Co-expression analysis among microRNAs, long non-coding RNAs, and messenger RNAs to understand the pathogenesis and progression of diabetic kidney disease at the genetic level

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收录情况： ◇ SCIE

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机构： [1]Department of Geriatric Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China [2]Department of Nephrology, First People’s Hospital of Yunnan Province, Kunming, Yunnan 650032, China [3]Computer Science Department, School of Computing, University of South Alabama, Mobile, AL 36688, USA [4]Department of Endocrinology and Metabolism, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China

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关键词： MicroRNA (miR) Long non-coding RNA (IncRNA) Diabetes Diabetic kidney disease (DM) Co-expression analysis Biomarker

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Diabetic kidney disease (DKD) is a serious disease that presents a major health problem worldwide. There is a desperate need to explore novel biomarkers to further facilitate the early diagnosis and effective treatment in DKD patients, thus preventing them from developing end-stage renal disease (ESRD). However, most regulation mechanisms at the genetic level in DKD still remain unclear. In this paper, we describe our innovative methodologies that integrate biological, computational, and statistical approaches to investigate important roles performed by regulations among microRNAs (miRs), long non-coding RNAs (lncRNAs), and messenger RNAs (mRNAs) in DKD. We conducted fully transparent, rigorously designed experiments. Our robust and reproducible results identified hsa-miR-223-3p as a candidate novel biomarker performing important roles in DKD disease process. (C) 2017 Published by Elsevier Inc.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 2 区生化研究方法 3 区生化与分子生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生化研究方法 3 区生化与分子生物学

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出版当年[2017]版：

Q1 BIOCHEMICAL RESEARCH METHODS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOCHEMICAL RESEARCH METHODS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 4.2 最新[2023版] 3.8 最新五年平均 3.998 出版当年[2017版] 3.936 出版当年五年平均 3.802 出版前一年[2016版] 3.782 出版后一年[2018版]

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第一作者机构： [1]Department of Geriatric Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China

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