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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

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机构: [1]Max Planck Inst Psycholinguist, Language Genet Dept, Nijmegen, Netherlands [2]Int Max Planck Res Sch Language Sci, Nijmegen, Netherlands [3]Yale Sch Med, Dept Psychiat, New Haven, CT 06519 USA [4]Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA USA [5]Univ So Calif, Inst Neuroimaging Informat, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA [6]Royal Coll Surg, Mol & Cellular Therapeut, Dublin 2, Ireland [7]Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behaviour, Donders Ctr Cognit Neuroimaging, Nijmegen, Netherlands [8]Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Psychiat, Kyoto, Japan [9]Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands [10]Univ Oslo, Inst Clin Med, NORMENT KG Jebsen Ctr, Oslo, Norway [11]Diakonhjemmet Hosp, Dept Res & Dev, Oslo, Norway [12]Karolinska Inst, Psychiat Sect, Dept Clin Neuroscience, Stockholm, Sweden [13]Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT KG Jebsen Ctr, Oslo, Norway [14]Radboud Univ Nijmegen Med Ctr, Donders Inst Brain Cognit & Behaviour, Dept Human Genet, Nijmegen, Netherlands [15]Radboud Univ Nijmegen Med Ctr, Donders Inst Brain Cognit & Behaviour, Dept Psychiat, Nijmegen, Netherlands [16]Radboud Univ Nijmegen Med Ctr, Dept Cognit Neuroscience, Nijmegen, Netherlands [17]Lagos State Univ, Dept Comp Sci, Lagos, Nigeria [18]Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland [19]Univ New S Wales UNSW, Sch Psychiat, Ctr Healthy Brain Ageing, Sydney, NSW, Australia [20]Murdoch Univ, Math & Stat, Murdoch, WA, Australia [21]Univ Munster, Dept Psychiat, Munster, Germany [22]Univ Paris Sud, Univ Paris Descartes Sorbonne Paris Cit, Inst Natl Sant, INSERM Unit 1000 Neuroimaging Psychiat, Paris, France [23]Univ Hosp Marques Valdecilla, Univ Cantabria IDIVAL, Sch Med, Dept Psychiat, Santander, Spain [24]Ctr Investigac Biom Red Salud Mental, CIBERSAM, Santander, Spain [25]Univ So Calif, Inst Neuroimaging Informat, Keck Sch Med, Imaging Genet Ctr, Los Angeles, CA USA [26]Med Fac Mannheim, Univ Heidelberg, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Sq J5, D-68159 Mannheim, Germany [27]Kings Coll London, Inst Psychiat Psychol Neuroscience, Ctr Neuroimaging Sci, London, England [28]Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland [29]Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland [30]Univ Edinburgh, Dept Neuroimaging Sci, Scottish Imaging Network Platform Sci Excellence, Edinburgh, Midlothian, Scotland [31]Univ Adelaide, Discipline Psychiat Sch Med, Adelaide, SA 5005, Australia [32]Texas Biomed Res Inst, Dept Genet, San Antonio, TX USA [33]Univ Texas Rio Grande Valley Sch Med, South Texas Diabet & Obes Inst, Brownsville, TX USA [34]Trin Coll Dublin, Discipline Sch Med, Trin Coll Inst Neurosciences, Dublin, Ireland [35]Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands [36]Vrije Univ Amsterdam Med Ctr, Dept Anat Neurosciences, Amsterdam, Netherlands [37]VU VUMC Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, Netherlands [38]Natl Inst Mental Hlth & Neurosciences, Dept Psychiat, Bangalore, Karnataka, India [39]Univ Zurich, Univ Clin & Adolescent Psychiat UCCAP, Zurich, Switzerland [40]Univ Zurich & ETH Zurich, Neuroscience Ctr Zurich, Zurich, Switzerland [41]Univ New South Wales, Sch Psychiat, Dementia Collaborat Res Ctr, Ctr Healthy Brain Ageing CHeBA, Sydney, NSW, Australia [42]Univ Med Ctr Hamburg Eppendorf, Martinistr, 3 OG, D-20246 Hamburg, Germany [43]Univ Cape Town, Dept Psychiat, Cape Town, South Africa [44]Raboud Univ, Donders Inst Brain Cognit & Behaviour, Nijmegen, Netherlands [45]Radboud Univ Nijmegen Med Ctr, Karakter Child & Adolescent Psychiat, Nijmegen, Netherlands [46]Univ New Mexico, Dept Elect & Comp Engn Neurosciences Comp Sci, Albuquerque, NM USA [47]Mind Res Network, Albuquerque, NM USA [48]Natl Univ Ireland Galway, Coll Med Nursing & Hlth Sci, Ctr Neuroimaging, Ctr Neuroimaging Cognit & Genom NICOG, Galway H91 TK33, Ireland [49]Kings Coll London, Inst Psychiat Psychol & Neuroscience, Med Res Council Social Genet & Dev Psychiat Ctr, London, England [50]First Affiliated Hosp Kunming Med Univ, Dept Psychiat, Kunming, Yunnan, Peoples R China [51]Univ Montreal, CHU Ste Justine Hosp, Dept Psychiat, Montreal, PQ, Canada [52]Kings Coll London, Inst Psychiat Psychol Neuroscience, Dept Psychol Med & Psychiat, London, England [53]Univ Wurzburg, Dept Psychol Biol Psychol Clin Psychol & Psychoth, Wurzburg, Germany [54]Univ Tubingen, Dept Child & Adolescent Psychiat & Psychotherapy, Tubingen, Germany [55]Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland [56]Univ Bordeaux 1, CNRS UMR 5296, CEA, Bordeaux, France [57]Univ Munster, Dept Psychiat, Munster, Germany [58]Univ Marburg, Dept Psychiat, Marburg, Germany [59]Queensland Univ Technol QUT, Fac Hlth & Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia [60]Natl Univ Ireland Galway, Sch Psychol & Discipline Biochem, Cognit Genet & Cognit Therapy Grp, Neuroimaging Cognit & Genom Ctr NICOG, SW4794 Galway, Ireland [61]Trinity Coll Dublin, Dept Psychiat & Trin Coll Inst Neuroscience, Dublin, Ireland [62]Sunnaas Rehabil Hosp HT, Nesodden, Norway [63]Univ Oslo, Dept Psychol, Oslo, Norway [64]Tech Univ Dresden, Dept Child & Adolescent Psychiat, Fac Med, Dresden, Germany [65]Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA [66]Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA [67]Univ Oslo, Dept Psychol, NORMENT KG Jebsen Ctr, Oslo, Norway [68]Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neuroscience, Mannheim, Germany [69]Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa [70]CEA Saclay Ctr, Neurospin, Commissariat Energie Atom, Paris, France [71]Natl Inst Physiol Sci, Div Cerebral Integrat, Okazaki, Aichi, Japan [72]Univ Med Ctr Hamburg Eppendorf UKE, Dept Psychiat & Psychotherapy, Martinistra 52, D-20246 Hamburg, Germany [73]Univ Vermont, Dept Psychiat & Psychol, Burlington, VT 05405 USA [74]Trinity Coll Inst Neuroscience, Trinity Coll, Dublin, Ireland [75]Univ Cantabria UC, Serv Neurol Univ Hosp Marquas Valdecilla IDIVAL, Santander, Spain [76]Ctr Investigac Biom Enfermedades Neurodegenerativ, CIBERNED, Madrid, Spain [77]Univ Nottingham, Univ Pk, Sir Peter Mansfield Imaging Ctr Sch Phys & Astron, Nottingham, England [78]Univ Med Greifswald, Dept Psychiat, Greifswald, Germany [79]HELIOS Hosp Stralsund, Dept Psychiat & Psychotherapy, Stralsund, Germany [80]Univ Munster, Dept Psychiat, Munster, Germany [81]Univ Med Ctr, Dept Psychiat & Psychotherapy, Ctr Translat Res Syst Neuroscience & Psychiat, D-37075 Gottingen, Germany [82]Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland [83]Osaka Univ, United Grad Sch Child Dev, Mol Res Ctr Childrens Mental Dev, Osaka, Japan [84]Osaka Univ Grad Sch Med, Dept Psychiat, Osaka, Japan [85]Univ Zurich, Univ Clin Child & Adolescent Psychiat UCCAP, Zurich, Switzerland [86]UCL, Wellcome Trust Ctr Neuroimaging, London, England [87]UCL, UCL Max Planck Ctr Computat Psychiat & Ageing, London, England [88]Universitatsmedizin Berlin, Dept Psychiat & Psychotherapy, Campus Charite Mitte Charite, Chariteplatz 1, Berlin, Germany [89]Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands [90]Shanghai Jiao Tong Univ Sch Med, Shanghai Mental Hlth Ctr, Wan Ping Nan Rd, 600, Shanghai 200030, Peoples R China [91]Acad Ctr Child & Adolescent Psychiat, De Bascule, Amsterdam, Netherlands [92]Dept Child & Adolescent Psychiat, AMC, Amsterdam, Netherlands [93]Physikalisch Tech Bundesanstalt PTB, Braunschweig, Germany [94]Univ Oslo, Inst Clin Med Psychiat sect, KG Jebsen Ctr Psychosis Res, NORMENT, Oslo, Norway [95]Tech Univ Dresden, Dept Psychiat & Neuroimaging Ctr, Dresden, Germany [96]Univ So Calif, Inst Neuroimaging Informat, Keck Sch Med, Imaging Genet Ctr, Los Angeles, CA 90292 USA [97]Univ Munster, Dept Clin Radiol, Munster, Germany [98]Seoul Natl Univ Coll Med, Dept Psychiat Behav Sci, Seoul, South Korea [99]Inst Human Behav Med, SNU MRC, Seoul, South Korea [100]Seoul Natl Univ, Dept Brain Cognit Sci, Coll Nat Sci, Seoul, South Korea [101]Univ Wurzburg, Div Mol Psychiat, Ctr Mental Hlth, Wurzburg, Germany [102]Maastricht Univ, Sch Mental Hlth & Neuroscience MHeNS, Dept Translat Neuroscience, Maastricht, Netherlands [103]Univ Stellenbosch, Dept Psychiat, MRC Unit Anxiety Stress Disorders Tygerberg, Tygerberg, South Africa [104]Kings Coll London, Inst Psychiat, Dept Neuroimaging, Ctr Neuroimaging Sci, London, England [105]QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia [106]Bellvitge Univ Hosp, Dept Psychiat, Inst Investigac Biomed Bellvitge IDIBELL, Barcelona, Spain [107]Univ Paris Sud, Univ Paris Descartes Sorbonne Paris Cit, Inst Natl Sant, INSERM Unit 1000 Neuroimaging Psychiat, Paris, France [108]Maison Solenn, Paris, France [109]Karolinska Inst, Dept Clin Neuroscience, Ctr Psychiat Res & Educ, Stockholm, Sweden [110]Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia [111]Inst Salud Carlos III, CIBER Salud Mental CIBERSAM, Barcelona, Spain [112]Univ Barcelona, Dept Clin Sci, Barcelona, Spain [113]UT Houston Med Sch, Dept Psychiat & Behav Sci, UT Ctr Excellence Mood Disorders, Houston, TX USA [114]Dept Neural Computat Decis Making, ATR Brain Informat Commun Res Lab Grp, Kyoto, Japan [115]Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiatry, Fukuoka, Japan [116]Univ Calif Los Angeles, Ctr Neurobehavioral Genet, Los Angeles, CA USA [117]Cochin Hosp, Dept Adolescent Psychopathol & Med, AP HP, Maison Solenn, Paris, France [118]Univ Wurzburg, Dept Psychiat & Psychotherapy, Wurzburg, Germany [119]Univ Toronto, Rotman Res Inst, Baycrest & Dept Psychol & Psychiat, M6A 2E1 Toronto, ON, Canada [120]Med Univ Vienna, Dept Child & Adolescent Psychiat & Psychotherapy, Vienna, Austria [121]Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Neuroscience Campus Amsterdam, Amsterdam, Netherlands [122]Univ Texas Hlth Sci Ctr, Dept Psychiat & Behav Sci, Houston, TX 77054 USA [123]Univ Autnoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona, Spain [124]Univ Cape Town, Dept Psychiat, MRC Unit Anxiety & Stress Disorders, Cape Town, South Africa [125]Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia [126]Inst Pasteur, Lab Human Genet & Cognit Funct, F-75015 Paris, France [127]Georgia State Univ, Dept Psychol, Atlanta, GA USA [128]Georgia State Univ, Dept Neuroscience, Atlanta, GA USA [129]Univ Cape Town, Dept Psychiat & Mental Hlth, Observ, Cape Town, South Africa [130]Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands [131]Univ Zurich, Neuroscience Ctr Zurich, ETH Zurich, Zurich, Switzerland [132]Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland [133]Univ Coll Dublin, Dept Psychol, Dublin, Ireland [134]German Ctr Neurodegenerat Dis DZNE, Site Rostock, Greifswald, Germany [135]Univ Queensland, Queensland Brain Inst & Ctr Adv Imaging, Brisbane, Qld, Australia [136]Seoul Natl Univ Hosp, Seoul, South Korea [137]Natl Univ Ireland Galway, Sch Psychol Discipline Biochem, Cognit Genet & Therapy Grp, Galway SW4794, Ireland [138]Yale Univ, Dept Psychiat, New Haven, CT 06511 USA [139]Olin Neuropsychiatr Res Ctr, Hartford, CT 06114 USA [140]Shaanxi Normal Univ, Sch Psychol, Xian, Peoples R China
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关键词: Subcortical brain asymmetry Age Handedness Sex Enigma Heritability Meta-analysis

摘要:
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 dataset worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

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出版当年[2018]版:
大类 | 2 区 医学
小类 | 3 区 神经成像
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 神经成像
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出版当年[2017]版:
Q2 NEUROIMAGING
最新[2023]版:
Q2 NEUROIMAGING

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第一作者:
第一作者机构: [1]Max Planck Inst Psycholinguist, Language Genet Dept, Nijmegen, Netherlands [2]Int Max Planck Res Sch Language Sci, Nijmegen, Netherlands
通讯作者:
通讯机构: [1]Max Planck Inst Psycholinguist, Language Genet Dept, Nijmegen, Netherlands [44]Raboud Univ, Donders Inst Brain Cognit & Behaviour, Nijmegen, Netherlands
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